L-655,708

Cat. No. 1327

L-655,708 C18H19N3O4 [130477-52-0]

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Chemical Name: 11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, ethyl ester

Biological Activity

Potent, selective inverse agonist for the benzodiazepine site of GABAA receptors containing the α5 subunit (Ki = 0.45 nM). Displays 50-100-fold selectivity over GABAA receptors containing α1, α2, α3 or α6 subunits in combination with β3 and γ2. Enhances LTP in  a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.

Technical Data

M.Wt:
341.37
Formula:
C18H19N3O4
Solubility:
Soluble to 25 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
130477-52-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Atack et al (2006) L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for α5-containing GABAA receptors. Neuropharmacology 51 1023. PMID: 17046030.

Sur et al (1998) Rat and human hippocampal α5 subunit-containing γ-aminobutyric acidA receptors have α5α3γ2 pharmacological characteristics. Mol.Pharmacol. 54 928. PMID: 9804628.

Quirk et al (1996) [3H]L-655,708, a novel ligand selective for the benzodiazepine site of GABAA receptors which contain the α5 subunit. Neuropharmacology 35 1331. PMID: 9014149.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for L-655,708 include:

Drexler et al (2013) Enhancing the function of alpha5-subunit-containing GABAA receptors promotes action potential firing of neocortical neurons during up-states. Eur J Pharmacol 703 18. PMID: 23380687.

Rüedi-Bettschen et al (2013) Modulation of α5 subunit-containing GABAA receptors alters alcohol drinking by rhesus monkeys. Alcohol Clin Exp Res 37 624. PMID: 23126673.

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Keywords: L-655,708, supplier, Selective, α5, alpha5, containing, a5, GABAA, receptors, Receptors, inverse, agonists, benzodiazepine, L655708, Tocris Bioscience, GABAA Receptor Benzodiazepine products

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