Cat. No. 1323
Chemical Name: (2S)-[1-[(2S)-2-amino-1-oxobutyl]-N
Biological ActivityPotent, reversible, selective and competitive inhibitor of a CCK-inactivating serine protease (tripeptidyl peptidase II) (Ki = 7 nM). Active in vivo (ID50 = 1.1 and 6.8 mg/kg i.v. for inhibition of liver and brain enzyme respectively).
Licensing InformationSold with the permission of INSERM and UCL
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Ganellin et al (2000) Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J.Med.Chem. 43 664. PMID: 10691692.
Renn et al (1998) Characterization and cloning of tripeptidyl peptidase II from the fruit fly, Drosophila melanogaster. J.Biol.Chem. 273 19173. PMID: 9668104.
Rose et al (1996) Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature 380 403. PMID: 8602240.
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Citations are publications that use Tocris products. Selected citations for Butabindide oxalate include:
Lorente et al (2011) Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells. J Biol Chem 286 38054. PMID: 21914809.
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Keywords: Butabindide oxalate, supplier, CCK-inactivating, serine, protease, inhibitors, inhibits, tripeptidyl, peptidase, II, Proteases, Proteinases, Cholecystokinin, Tocris Bioscience, Other Protease Inhibitor products
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