Butabindide oxalate

Cat. No. 1323

Butabindide oxalate C17H25N3O2.C2H2O4 [185213-03-0]

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Chemical Name: (2S)-[1-[(2S)-2-amino-1-oxobutyl]-N-butyl]-2,3-dihydro-1H-indole-2-carboxamide oxalate

Biological Activity

Potent, reversible, selective and competitive inhibitor of a CCK-inactivating serine protease (tripeptidyl peptidase II) (Ki = 7 nM). Active in vivo (ID50 = 1.1 and 6.8 mg/kg i.v. for inhibition of liver and brain enzyme respectively).

Licensing Information

Sold with the permission of INSERM and UCL

Technical Data

M.Wt:
393.44
Formula:
C17H25N3O2.C2H2O4
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
185213-03-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Ganellin et al (2000) Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J.Med.Chem. 43 664. PMID: 10691692.

Renn et al (1998) Characterization and cloning of tripeptidyl peptidase II from the fruit fly, Drosophila melanogaster. J.Biol.Chem. 273 19173. PMID: 9668104.

Rose et al (1996) Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature 380 403. PMID: 8602240.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Butabindide oxalate include:

Lorente et al (2011) Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells. J Biol Chem 286 38054. PMID: 21914809.

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Keywords: Butabindide oxalate, supplier, CCK-inactivating, serine, protease, inhibitors, inhibits, tripeptidyl, peptidase, II, Proteases, Proteinases, Cholecystokinin, Tocris Bioscience, Other Protease Inhibitor products

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