BD 1047 dihydrobromide

Cat. No. 0956

BD 1047 dihydrobromide C13H20Cl2N2.2HBr [138356-21-5]

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Chemical Name: N-[2-(3,4-Dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide

Biological Activity

σ1 receptor antagonist, exhibiting a similar binding profile to that of BD 1063 (Cat. No. 0883) but with higher affinity (approximately 10-fold) at both σ1 and σ2 sites.

Technical Data

M.Wt:
437.04
Formula:
C13H20Cl2N2.2HBr
Solubility:
Soluble to 50 mM in water and to 50 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
138356-21-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Garrone et al (2000) Effects of trazodone on neurotransmitter release from rat mossy fibre cerebellar synaptosomes. Eur.J.Pharmacol. 400 35. PMID: 10913582.

Romieu et al (2000) Involvement of the sigma1 receptor in the cocaine-induced conditioned place preference. Neuroreport 11 2885. PMID: 11006959.

Matsumoto et al (1995) Characterisation of two novel σ receptor ligands: antidystonic effects in rats suggest σ receptor antagonism. Eur.J.Pharmacol. 280 301. PMID: 8566098.

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Citations are publications that use Tocris products. Selected citations for BD 1047 dihydrobromide include:

Rodríguez-Muñoz et al (2015) The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders. Int J Neuropsychopharmacol 6 35458. PMID: 26461475.

Gear et al (2014) NOP receptor mediates anti-analgesia induced by agonist-antagonist opioids. Neuroscience 257 139. PMID: 24188792.

Nguyen et al (2014) Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan. PLoS One 9 e89985. PMID: 24587167.

Pan et al (2014) σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons. Exp Ther Med 350 290. PMID: 24891452.

Sánchez-Blázquez et al (2014) The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. Korean J Physiol Pharmacol 17 1943. PMID: 24485144.

Su et al (2014) Effects of BD1047, aσ1 receptor antagonist, on the expression of mTOR, Camk2γ and GSK-3β in fluvoxamine-treated N2a cells. Oncotarget 7 435. PMID: 24396420.

Kourrich et al (2013) Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine. Cell 152 236. PMID: 23332758.

Hiranita et al (2011) Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors. J Pharmacol Exp Ther 339 662. PMID: 21859929.

Son and Kwon (2010) σ-1 Receptor Antagonist BD1047 Reduces Allodynia and Spinal ERK Phosphorylation Following Chronic Compression of Dorsal Root Ganglion in Rats. J Neurophysiol 14 359. PMID: 21311675.

Kwon et al (2009) The Antinociceptive Effect of σ-1 Receptor Antagonist, BD1047, in a Capsaicin Induced Headache Model in Rats. Br J Ophthalmol 13 425. PMID: 20054487.

Yoon et al (2009) Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABA receptors. Br J Pharmacol 157 666. PMID: 19422393.

Cantarella et al (2007) Protective effects of the σ agonist Pre-084 in the rat retina. Korean J Physiol Pharmacol 91 1382. PMID: 17522150.

Shin et al (2005) The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan. Br J Pharmacol 144 908. PMID: 15723099.

Brown et al (2004) Antitussive activity of sigma-1 receptor agonists in the guinea-pig. Br J Pharmacol 141 233. PMID: 14691051.

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Keywords: BD 1047 dihydrobromide, supplier, σ1, sigma1, selective, antagonist, receptors, BD1047, dihydrobromide, Tocris Bioscience, σ1 Receptor Antagonist products

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