Cat. No. 1312
Chemical Name: [[4-Chloro-6-[(2,3-dimethylphenyl)a
Biological ActivitySelective PPARα agonist (EC50 values are 0.63, 32 and > 100 μM at PPARα, PPARγ and PPARδ respectively). Negatively inhibits NF-κB transcriptional activity and decreases the inflammatory response in vitro and in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Bishop-Bailey (2000) Peroxisome proliferator-activated receptors in the cardiovascular system. Br.J.Pharmacol. 129 823. PMID: 10696077.
Willson et al (2000) The PPARs: from orphan receptors to drug discovery. J.Med.Chem. 43 527. PMID: 10691680.
Forman et al (1997) Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc.Natl.Acad.Sci.U.S.A. 94 4312. PMID: 9113986.
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Citations are publications that use Tocris products. Selected citations for WY 14643 include:
Oruqaj et al (2015) Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling. Proc Natl Acad Sci U S A 112 E2048. PMID: 25848047.
Rizvi et al (2013) Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis. Vascul Pharmacol 59 144. PMID: 24050945.
Bumpus and Johnson (2011) 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated protein kinase-independent. Mol Psychiatry 339 886. PMID: 21896918.
Mascia et al (2011) Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. Biol Psychiatry 69 633. PMID: 20801430.
Ropero et al (2009) Rapid non-genomic regulation of Ca2+ signals and insulin secretion by PPAR alpha ligands in mouse pancreatic islets of Langerhans. J Endocrinol 200 127. PMID: 19017711.
Melis et al (2008) Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors. J Neurosci 28 13985. PMID: 19091987.
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Keywords: WY 14643, supplier, Selective, PPARα, PPARalpha, agonists, Peroxisome-Proliferator, Receptors, PPARs, WY14643, Tocris Bioscience, PPARα Agonist products
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