RS 100329 hydrochloride

Cat. No. 1325

RS 100329 hydrochloride C20H25F3N4O3.HCl [1215654-26-4]

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Chemical Name: 5-Methyl-3-[3-[3-[4-[2-(2,2,2,-trifluroethoxy)phenyl]-1-piperazinyl]propyl]-2,4-(1H,3H)-pyrimidinedione hydrochloride

Biological Activity

Subtype-selective α1A-adrenoceptor antagonist (pKi = 9.6 for human cloned α1A receptors). Displays 126- and 50-fold selectivity over human α1B and α1D receptors respectively. Active in vivo.

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data

M.Wt:
462.89
Formula:
C20H25F3N4O3.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
1215654-26-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Conley et al (2001) The role of α1-adrenoceptors and 5-HT1A receptors in the control of the micturition reflex in male anaesthetized rats. Br.J.Pharmacol. 133 61. PMID: 11325795.

Williams et al (1999) In vitro α1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel α1A-adrenoceptor selective antagonists. Br.J.Pharmacol. 127 252. PMID: 10369480.

Shannon Kava et al (1998) α1L-Adrenoceptor mediation of smooth muscle contraction in rabbit bladder neck: a model for lower urinary tract tissues of man. Br.J.Pharmacol. 123 1359. PMID: 9579731.

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Citations are publications that use Tocris products. Selected citations for RS 100329 hydrochloride include:

Zacharia et al (2013) High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via α1A- and α1D-adrenoceptor subtypes. PLoS One 8 e65969. PMID: 23776582.

Cleary et al (2004) Sympathectomy reveals alpha 1A- and alpha 1D-adrenoceptor components to contractions to noradrenaline in rat vas deferens. Br J Pharmacol 143 745. PMID: 15451776.

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