(RS)-Baclofen

Cat. No. 0417

(RS)-Baclofen C10H12ClNO2 [1134-47-0]

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Chemical Name: (RS)-4-Amino-3-(4-chlorophenyl)butanoic acid

Biological Activity

Selective GABAB receptor agonist. Skeletal muscle relaxant. (R)-Baclofen (Cat. No. 0796) also available.

Technical Data

M.Wt:
213.66
Formula:
C10H12ClNO2
Solubility:
Soluble to 100 mM in 1eq. NaOH
Purity:
>99 %
Storage:
Store at RT
CAS No:
1134-47-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Bowery et al (1993) GABAB receptor pharmacology. Annu.Rev.Pharmacol.Toxicol. 33 109. PMID: 8388192.

Berthelot et al (1991) 3-Thienylaminobutyric acid and 3-furylaminobutyric acids - synthesis and GABAB receptor binding studies. J.Med.Chem. 34 2557. PMID: 1652022.

Hill et al (1981) 3H-Baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain. Nature 290 149. PMID: 6259535.

If you know of a relevant reference for (RS)-Baclofen please let us know.

Citations are publications that use Tocris products. Selected citations for (RS)-Baclofen include:

Baquero et al (2015) Developmental changes in synaptic distribution in arcuate nucleus neurons. Neuropsychopharmacology 35 8558. PMID: 26041922.

Bell et al (2015) Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation. J Neurophysiol 9 115. PMID: 25918499.

Rubio et al (2015) Context-induced reinstatement of methamphetamine seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons. J Neurosci 35 5625. PMID: 25855177.

Terunuma et al (2015) Purinergic receptor activation facilitates astrocytic GABAB receptor calcium signalling. Front Cell Neurosci 88 74. PMID: 25261019.

Wojnicki et al (2013) Baclofen-induced reductions in optional food intake depend upon food composition. Appetite 64 62. PMID: 23321345.

Zemoura et al (2013) Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptors. J Biol Chem 288 34897. PMID: 24114844.

Baloucoune et al (2012) GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation. PLoS One 7 e39698. PMID: 22761875.

Olmos-Serrano et al (2010) Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome. Neuropharmacology 30 9929. PMID: 20660275.

Takesian et al (2010) Presynaptic GABA(B) receptors regulate experience-dependent development of inhibitory short-term plasticity. J Neurosci 30 2716. PMID: 20164356.

Tu et al (2010) GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation. J Neurosci 30 749. PMID: 20071540.

Bray and Mynlieff (2009) Influx of calcium through L-type calcium channels in early postnatal regulation of chloride transporters in the rat hippocampus. Dev Neurobiol 69 885. PMID: 19777558.

Maher and Westbrook (2008) Co-transmission of dopamine and GABA in periglomerular cells. J Neurosci 99 1559. PMID: 18216231.

Petzold et al (2008) Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways. J Neurosci 58 897. PMID: 18579080.

Jakubs et al (2006) Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability. Neuron 52 1047. PMID: 17178407.

Do you know of a great paper that uses (RS)-Baclofen from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: (RS)-Baclofen, supplier, Selective, GABAB, agonists, Receptors, Tocris Bioscience, GABAB Receptor Agonist products

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