(RS)-Baclofen

Cat. No. 0417

(RS)-Baclofen C10H12ClNO2 [1134-47-0]

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Chemical Name: (RS)-4-Amino-3-(4-chlorophenyl)butanoic acid

Biological Activity

Selective GABAB receptor agonist. Skeletal muscle relaxant. (R)-Baclofen (Cat. No. 0796) also available.

Technical Data

M.Wt:
213.66
Formula:
C10H12ClNO2
Solubility:
Soluble to 100 mM in 1eq. NaOH
Purity:
>99 %
Storage:
Store at RT
CAS No:
1134-47-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Bowery et al (1993) GABAB receptor pharmacology. Annu.Rev.Pharmacol.Toxicol. 33 109. PMID: 8388192.

Berthelot et al (1991) 3-Thienylaminobutyric acid and 3-furylaminobutyric acids - synthesis and GABAB receptor binding studies. J.Med.Chem. 34 2557. PMID: 1652022.

Hill et al (1981) 3H-Baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain. Nature 290 149. PMID: 6259535.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for (RS)-Baclofen include:

Rubio et al (2015) Context-induced reinstatement of methamphetamine seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons. J Neurosci 35 5625. PMID: 25855177.

Wojnicki et al (2013) Baclofen-induced reductions in optional food intake depend upon food composition. Appetite 64 62. PMID: 23321345.

Zemoura et al (2013) Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptors. J Biol Chem 288 34897. PMID: 24114844.

Baloucoune et al (2012) GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation. PLoS One 7 e39698. PMID: 22761875.

Takesian et al (2010) Presynaptic GABA(B) receptors regulate experience-dependent development of inhibitory short-term plasticity. J Neurosci 30 2716. PMID: 20164356.

Tu et al (2010) GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation. J Neurosci 30 749. PMID: 20071540.

Bray and Mynlieff (2009) Influx of calcium through L-type calcium channels in early postnatal regulation of chloride transporters in the rat hippocampus. Dev Neurobiol 69 885. PMID: 19777558.

Jakubs et al (2006) Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability. Neuron 52 1047. PMID: 17178407.

Do you know of a great paper that uses (RS)-Baclofen from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Product Action

Keywords: (RS)-Baclofen, supplier, Selective, GABAB, agonists, Receptors, Tocris Bioscience, GABAB Receptor Agonist products

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