Picrotoxin

Cat. No. 1128

Picrotoxin C30H34O13 [124-87-8]

Price and Availability

For Picrotoxin pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Biological Activity

GABAA receptor antagonist; potent CNS stimulant.

Technical Data

M.Wt:
602.59
Formula:
C30H34O13
Solubility:
Soluble to 50 mM in ethanol with gentle warming and to 100 mM in DMSO
Storage:
Store at RT
CAS No:
124-87-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Ette et al (1999) Picrotoxin blockade of inverterbrate glutamate-gated chloride channels: subunit dependence and evidence for binding within the pore. J.Neurochem. 72 318. PMID: 9886084.

Dillon et al (1995) Enhancement by GABA of the association rate of picrotoxin and tert-butylbicyclophosphorothionate to the rat cloned α1β2γ2 GABAA receptor subtype. Br.J.Pharmacol. 115 539. PMID: 7582470.

Newland and Cull-Candy (1992) On the mechanism of action of picrotoxin on GABA receptor channels in dissociated sympathetic neurones of the rat. J.Physiol. 447 191. PMID: 1317428.

Merck Index 12 7570.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Picrotoxin include:

Tozzi et al (2015) Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system. Front Cell Neurosci 9 192. PMID: 26074768.

An et al (2014) Neuritin can normalize neural deficits of Alzheimer's disease. Cell Death Dis 5 e1523. PMID: 25393479.

Eales et al (2014) The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility. Nat Commun 5 4701. PMID: 25134715.

Easton et al (2014) Genetic elimination of GABAergic neurotransmission reveals two distinct pacemakers for spontaneous waves of activity in the developing mouse cortex. J Neurosci 34 3854. PMID: 24623764.

Simon et al (2014) Gap junction networks can generate both ripple-like and fast ripple-like oscillations. Eur J Neurosci 39 46. PMID: 24118191.

Tani et al (2014) A local glutamate-glutamine cycle sustains synaptic excitatory transmitter release. Neuron 81 888. PMID: 24559677.

Wang et al (2014) SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks. PLoS One 8 e83941. PMID: 24391850.

Xia et al (2014) Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons. PLoS One 9 e100968. PMID: 24971996.

Beckley et al (2013) Medial prefrontal cortex inversely regulates toluene-induced changes in markers of synaptic plasticity of mesolimbic dopamine neurons. J Neurosci 33 804. PMID: 23303956.

Hou and Yu (2013) Activity-regulated somatostatin expression reduces dendritic spine density and lowers excitatory synaptic transmission via postsynaptic somatostatin receptor 4. J Biol Chem 288 2501. PMID: 23233668.

Neuser et al (2013) Region-specific integration of embryonic stem cell-derived neuronal precursors into a pre-existing neuronal circuit. PLoS One 8 e66497. PMID: 23840491.

Rehak et al (2013) Low voltage activation of KCa1.1 current by Cav3-KCa1.1 complexes. PLoS One 8 e61844. PMID: 23626738.

Caiati et al (2012) Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses. Sci Rep 2 285. PMID: 22368777.

Ermolyuk et al (2012) Independent regulation of basal neurotransmitter release efficacy by variable Ca2+ influx and bouton size at small central synapses. PLoS Biol 10 e1001396. PMID: 23049481.

Hemond et al (2012) Simulated GABA synaptic input and L-type calcium channels form functional microdomains in hypothalamic gonadotropin-releasing hormone neurons. J Neurosci 32 8756. PMID: 22745478.

Janssen et al (2012) Neuregulin directly decreases voltage-gated sodium current in hippocampal ErbB4-expressing interneurons. J Neurosci 32 13889. PMID: 23035098.

Lugo et al (2012) Kv4.2 knockout mice have hippocampal-dependent learning and memory deficits. Learn Mem 19 182. PMID: 22505720.

Olsen and Sheng (2012) NMDA receptors and BAX are essential for Aβ impairment of LTP. Sci Rep 2 225. PMID: 22355739.

Ring et al (2012) GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium. PLoS One 7 e36874. PMID: 22590629.

Wills et al (2012) GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis. Proc Natl Acad Sci U S A 109 E278. PMID: 22219357.

Yoon et al (2012) Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway. Mol Brain 5 40. PMID: 23111145.

Etherton et al (2011) An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus. EMBO J 30 2908. PMID: 21642956.

George et al (2011) A diversity of synaptic filters are created by temporal summation of excitation and inhibition. J Neurosci 31 14721. PMID: 21994388.

Higley et al (2011) Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS One 6 e19155. PMID: 21544206.

Parker et al (2011) Attenuating GABA(A) receptor signaling in dopamine neurons selectively enhances reward learning and alters risk preference in mice. J Neurosci 31 17103. PMID: 22114279.

Storey et al (2011) Molecular determinants controlling NMDA receptor synaptic incorporation. J Neurosci 31 6311. PMID: 21525271.

Straub et al (2011) Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1. Nat Neurosci 14 866. PMID: 21623363.

Wang et al (2011) A critical role for GluN2B-containing NMDA receptors in cortical development and function. Neuron 72 789. PMID: 22153375.

Bhat et al (2010) Inhibitory role for GABA in autoimmune inflammation. Proc Natl Acad Sci U S A 107 2580. PMID: 20133656.

Buchanan et al (2010) Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels. Neuron 68 948. PMID: 21145007.

Goffin et al (2010) Dopamine-dependent tuning of striatal inhibitory synaptogenesis. J Neurosci 30 2935. PMID: 20181591.

Jackson et al (2010) Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase. PLoS One 5 e11962. PMID: 20694145.

Kaneko et al (2010) Constitutively active H-ras accelerates multiple forms of plasticity in developing visual cortex. Proc Natl Acad Sci U S A 107 19026. PMID: 20937865.

Lobb et al (2010) A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons. J Neurophysiol 104 403. PMID: 20445035.

Nishino et al (2010) A glycine receptor is involved in the organization of swimming movements in an invertebrate chordate. BMC Neurosci 11 6. PMID: 20085645.

Shiratsuchi et al (2009) Propofol inhibits pressure-stimulated macrophage phagocytosis via the GABAA receptor and dysregulation of p130cas phosphorylation. Am J Physiol Cell Physiol 296 C1400. PMID: 19357231.

Andäng et al (2008) Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation. Nature 451 460. PMID: 18185516.

Costa et al (2008) Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition. J Neurosci 28 8040. PMID: 18685029.

Frischknecht et al (2008) Activity-induced synaptic capture and exocytosis of the neuronal serine protease neurotrypsin. J Neurosci 28 1568. PMID: 18272678.

Jüngling et al (2008) Neuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdala. Neuron 59 298. PMID: 18667157.

Root et al (2008) A presynaptic gain control mechanism fine-tunes olfactory behavior. Neuron 59 311. PMID: 18667158.

Inan et al (2006) Barrel map development relies on protein kinase A regulatory subunit II beta-mediated cAMP signaling. J Neurosci 26 4338. PMID: 16624954.

Kopp et al (2006) Insufficient sleep reversibly alters bidirectional synaptic plasticity and NMDA receptor function. J Neurosci 26 12456. PMID: 17135407.

Smith and Otis (2005) Pattern-dependent, simultaneous plasticity differentially transforms the input-output relationship of a feedforward circuit. Proc Natl Acad Sci U S A 102 14901. PMID: 16199519.

Do you know of a great paper that uses Picrotoxin from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Target

View Related Products by Product Action

Keywords: Picrotoxin, supplier, GABAA, receptor, antagonists, Receptors, picrotin, Tocris Bioscience, GABAA Receptor Antagonist products

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

GABA Review

Written by I. Martin et al

GABA Receptors Scientific Review

Our GABA review gives an overview of the structure and function of the GABA receptors, as well as highlighting pharmacological ligands for their study. Request copy or view PDF today.

divider line

Peripheral Sensitization

Written by Grant D. Nicol and Michael R. Vasko

Pain Life Science Poster

Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request copy or view PDF today.

divider line

Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

Schizophrenia Life Science Poster

Our Schizophrenia poster higlights the targets and pathways representing the most promising strategies to pursue for novel drug development. Request copy today.

divider line

Mechanisms of Addiction

Addiction Life Science Poster

Written by Prof David Nutt, this poster summarizes the brain circuits and neurotransmitter systems that are affected by the main classes of addictive drugs. Request copy or view PDF today.

divider line

Bio-Techne Events

IVBM 2016

IVBM 2016

October 30 - November 3, 2016

Boston, MA, USA

Booth: 2