8-Bromo-cGMP, sodium salt

Cat. No. 1089

8-Bromo-cGMP, sodium salt C10H10BrN5NaO7P [51116-01-9]

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Chemical Name: 8-Bromoguanosine cyclic 3',5'-monophosphate sodium salt

Biological Activity

Membrane permeable cGMP analog that activates protein kinase G (PKG). 4.3-fold more potent than cGMP in activating PKG1α and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro.

Technical Data

M.Wt:
446.09
Formula:
C10H10BrN5NaO7P
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
51116-01-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Sekhar et al (1992) Relaxation of pig coronary arteries by new and potent cGMP analogs that selectively activate type 1α, compared with type 1β, cGMP-dependent protein kinase. Mol.Pharmacol. 42 103. PMID: 1321950.

Buchan et al (1991) Modulation of agonist-induced calcium mobilisation in bovine aortic endothelial cells by phorbol myristate acetate and cyclic AMP but not cyclic GMP. Br.J.Pharmacol. 104 361. PMID: 1665733.

Ignarro et al (1974) Stimulation of phagocytic release of neutral protease from human neutrophils by cholinergic amines and cyclic 3',5'-guanosine monophosphate. J.Immunol. 112 210. PMID: 4359834.

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Keywords: 8-Bromo-cGMP, sodium salt, supplier, cGMP, analog, activates, PKG, protein, kinase, G, activator, Tocris Bioscience, G Protein (Heterotrimeric) products

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