Cat. No. 0655
Chemical Name: N,N,6-Trimethyl-2-(4-methylphenyl)i
Biological ActivityBenzodiazepine agonist with high selectivity for α1-subunit-containing GABAA receptors (BZ/ω1 site) and very high intrinsic activity. Ki values are 20, 400 and ≥ 5000 nM for α1-, α2-/α3-, and α5-containing GABAA receptors respectively. Hypnotic that does not induce physical dependence.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Crestani et al (2000) Mechanism of action of the hypnotic zolpidem in vivo. Br.J.Pharmacol. 131 1251. PMID: 11090095.
Perrault et al (1992) Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zolpidem. J.Pharmacol.Exp.Ther. 263 298. PMID: 1403792.
Arbilla et al (1986) High affinity [3H]zolpidem binding in the rat brain: an imidazopyridine with agonist properties at central benzodiazepine receptors. Eur.J.Pharmacol. 130 257. PMID: 2878820.
Depoortere et al (1986) Zolpidem, a novel nonbenzodiazepine hypnotic. 1. Neuropharmacological and behavioural effects. J.Pharmacol.Exp.Ther. 237 649. PMID: 2871178.
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Citations are publications that use Tocris products. Selected citations for Zolpidem include:
Letra-Vilela et al (2016) Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin Molecular and Cellular Endocrinology 434 238. PMID: 27402603.
Seifi et al (2014) Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon. Br J Cancer 34 10361. PMID: 25080596.
Lazarus and Huang (2011) Distinct maturation profiles of perisomatic and dendritic targeting GABAergic interneurons in the mouse primary visual cortex during the critical period of ocular dominance plasticity. J Neurophysiol 106 775. PMID: 21613595.
Kotak et al (2008) Hearing loss prevents the maturation of GABAergic transmission in the auditory cortex. J Neurosci 18 2098. PMID: 18222937.
Bowser et al (2002) Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy. Proc Natl Acad Sci U S A 99 15170. PMID: 12415111.
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Keywords: Zolpidem, supplier, Benzodiazepine, agonists, GABAA, Receptors, Tocris Bioscience, GABAA Receptor Benzodiazepine products