ZD 7114 hydrochloride
Cat. No. 0930
Alternative Name: ICI D7114
Chemical Name: (S)-4-[2-Hydroxy-3-phenoxypropylami
Biological Activityβ3-adrenoceptor agonist. Active metabolite ICI 215,001 hydrochloride (Cat. No. 0929) also available.
Licensing InformationSold with the permission of AstraZeneca UK Ltd .
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
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Savontaus et al (1998) Effects of ZD7114, a selective β3-adrenoceptor agonist, on neuroendocrine mechanisms controlling energy balance. Eur.J.Pharmacol. 347 265. PMID: 9653893.
Growcott et al (1993) Evaluation of ICI D7114, a putative stimulant of brown adipocytes, on histamine-contracted guinea-pig ileum. Br.J.Pharmacol. 109 1212. PMID: 8104647.
How (1993) β3-Adrenergic agonists. Drugs Future 18 529.
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Citations are publications that use Tocris products. Selected citations for ZD 7114 hydrochloride include:
Suárez et al (2014) Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat. Dis Model Mech 7 129. PMID: 24159189.
Baker et al (2011) Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses. FASEB J 25 4486. PMID: 21865315.
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