ZD 7114 hydrochloride

Cat. No. 0930

ZD 7114 hydrochloride C22H30N2O6.HCl
 [129689-28-7]

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Alternative Name: ICI D7114

Chemical Name: (S)-4-[2-Hydroxy-3-phenoxypropylaminoethoxy]-N-(2-methoxyethyl)phenoxyacetamide hydrochloride

Biological Activity

β3-adrenoceptor agonist. Active metabolite ICI 215,001 hydrochloride (Cat. No. 0929) also available.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd .

Technical Data

M.Wt:
454.95
Formula:
C22H30N2O6.HCl
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at RT
CAS No:
129689-28-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service

Savontaus et al (1998) Effects of ZD7114, a selective β3-adrenoceptor agonist, on neuroendocrine mechanisms controlling energy balance. Eur.J.Pharmacol. 347 265. PMID: 9653893.

Growcott et al (1993) Evaluation of ICI D7114, a putative stimulant of brown adipocytes, on histamine-contracted guinea-pig ileum. Br.J.Pharmacol. 109 1212. PMID: 8104647.

How (1993) β3-Adrenergic agonists. Drugs Future 18 529.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for ZD 7114 hydrochloride include:

Suárez et al (2014) Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat. Dis Model Mech 7 129. PMID: 24159189.

Baker et al (2011) Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses. FASEB J 25 4486. PMID: 21865315.

Do you know of a great paper that uses ZD 7114 hydrochloride from Tocris? If so please let us know.

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