Zaprinast

Cat. No. 0947

Zaprinast C13H13N5O2 [37762-06-4]

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Chemical Name: 2-(2-Propyloxyphenyl)-8-azapurin-6-one

Biological Activity

Phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC50 values are 0.15, 0.76, 12.0 and 29.0 μM respectively). Putative GPR35 agonist.

Technical Data

M.Wt:
271.28
Formula:
C13H13N5O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
37762-06-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Lugnier (2006) Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents. Pharmacol.Ther. 109 366. PMID: 16102838.

Taniguchi et al (2006) Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35. FEBS Lett. 580 5003. PMID: 16934253.

Soderling et al (1998) Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J.Biol.Chem. 273 15553. PMID: 9624145.

Christensen and Torphy (1994) Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents. Annu.Rep.Med.Chem. 29 185.

If you know of a relevant reference for Zaprinast please let us know.

Citations are publications that use Tocris products. Selected citations for Zaprinast include:

Polcari et al (2013) Effect of the phosphodiesterase-5 inhibitor zaprinast on ischemia-reperfusion injury in rats. Proc Natl Acad Sci U S A 27 338. PMID: 22974473.

Zerani et al (2004) Ob receptor in rabbit ovary and leptin in vitro regulation of corpora lutea. J Endourol 183 279. PMID: 15531716.

Do you know of a great paper that uses Zaprinast from Tocris? If so please let us know.

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Keywords: Zaprinast, supplier, PDE5/6/9/11, inhibitors, inhibits, Phosphodiesterases, Tocris Bioscience, GPR35 Agonist products

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