Cat. No. 0380
Chemical Name: N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-c
Biological ActivityA selective and potent 5-HT3 antagonist (Ki = 2.9 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Haga et al (1993) The effects of orally administered Y-25130, a selective serotonin3 receptor antagonist on chemotherapeutic agent-induced emesis. Jpn.J.Pharmacol. 63 377. PMID: 8107329.
Sato et al (1992) Antagonistic activity of Y-25130 on 5-HT3 receptors. Jpn.J.Pharmacol. 59 443. PMID: 1331590.
Fukuda et al (1991) The antiemetic profile of Y-25130, a new selective 5-HT3 receptor antagonist. Eur.J.Pharmacol. 196 299. PMID: 1654255.
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Citations are publications that use Tocris products. Selected citations for Y-25130 hydrochloride include:
Xiao et al (2008) Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling. Proc Natl Acad Sci U S A 4 12. PMID: 18416824.
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Keywords: Y-25130 hydrochloride, supplier, Potent, selective, 5-HT3, antagonists, Serotonin, Receptors, Tocris Bioscience, 5-HT3 Receptor Antagonist products