Xamoterol hemifumarate

Cat. No. 0950

Xamoterol hemifumarate C16H25N3O5.0.5C4H4O4 [73210-73-8]

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Alternative Name: ICI 118,587

Chemical Name: 1-(4-Hydroxyphenoxy)-3-[2-(4-morpholinocarboxamido)ethylamino]-2-propanol hemifumarate

Biological Activity

β1-adrenoceptor-selective partial agonist (pA2 values are 7.4 - 7.8 and 5.2 - 6.2 at β1- and β2-adrenoceptors respectively).

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M.Wt:
397.43
Formula:
C16H25N3O5.0.5C4H4O4
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
>97 %
Storage:
Store at RT
CAS No:
73210-73-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Malta et al (1985) The in vitro pharmacology of xamoterol (ICI 118,587). Br.J.Pharmacol. 85 179. PMID: 2862938.

Nuttall and Snow (1982) The cardiovascular effects of ICI 118,587: a β1-adrenoceptor partial agonist. Br.J.Pharmacol. 77 381. PMID: 6128041.

Barlow et al (1981) β-Adrenoceptor stimulant properties of aminoalkylamino-substituted 1-aryl-2-ethanols and 1-(aryloxy)-2-propanols. J.Med.Chem. 24 315. PMID: 6115058.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Xamoterol hemifumarate include:

Creed et al (2015) β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion. Breast Cancer Res 17 145. PMID: 26607426.

Lavine et al (2013) Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism. JAMA Ophthalmol 131 376. PMID: 23303344.

Baker et al (2011) Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses. FASEB J 25 4486. PMID: 21865315.

Rankovic et al (2011) Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons. PLoS One 6 e27474. PMID: 22164209.

Skeberdis et al (1997) Pharmacological characterization of the receptors involved in the beta-adrenoceptor-mediated stimulation of the L-type Ca2+ current in frog ventricular myocytes. Br J Pharmacol 121 1277. PMID: 9257904.

Do you know of a great paper that uses Xamoterol hemifumarate from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Xamoterol hemifumarate, supplier, β1-adrenoceptors, α1-adrenoceptor, beta1-adrenoceptors, β1-Adrenergic, beta1-Adrenergic, b1-adrenergic, b1-adrenoceptors, selective, partial, agonists, Receptors, ICI118587, AstraZeneca, Tocris Bioscience, Adrenergic β1 Receptor Agonist products

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