W-84 dibromide

Cat. No. 0532

W-84 dibromide C32H44Br2N4O4 [21093-51-6]

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Chemical Name: Hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium]dibromide

Biological Activity

Stabilizes cholinergic antagonist-receptor complexes by an allosteric effect. Increases the protective effect of atropine against organophosphate poisoning.

Technical Data

M.Wt:
708.53
Formula:
C32H44Br2N4O4
Solubility:
Soluble to 10 mM in DMSO
Storage:
Store at RT
CAS No:
21093-51-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Mohr et al (1992) Equipotent allosteric effect of W84 on [3H]-NMS binding to cardiac muscarinic receptors from guinea-pig, rat and pig. Pharmacol.Toxicol. 70 198. PMID: 1579545.

Jepsen et al (1988) Allosteric stabilisation of [3H]-N-methylscopolamine binding in guinea pig myocardium by an antidote against organophosphate intoxication. Pharmacol.Toxicol. 63 163. PMID: 3054859.

Mitchelson (1975) Antimuscarinic action of an alkane-bis ammonium compound alone and in combination with (+)-bensetimide. Eur.J.Pharmacol. 33 237. PMID: 1242377.

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Keywords: W-84 dibromide, supplier, antagonists-receptor, complex, stabilizer, Muscarinic, Receptors, Acetylcholine, ACh, Tocris Bioscience, Non-selective Muscarinic Antagonist products

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