W-7 hydrochloride

Cat. No. 0369

W-7 hydrochloride C16H21ClN2O2S.HCl

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Chemical Name: N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride

Biological Activity

Calmodulin antagonist. Inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 μM) and myosin light chain kinase (IC50 = 51 μM).

Technical Data

Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Asano et al (1989) Divergent pharmacological effects of three calmodulin antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W 7), chlorpromazine and calmidazolium, on isometric tension development and myosin light chain phosphorylation in intact bovine tracheal smooth muscle. J.Pharmacol.Exp.Ther. 251 764. PMID: 2810127.

Itoh and Hidaka (1984) Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase. J.Biochem. 96 1721. PMID: 6099352.

Hidaka et al (1981) N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc.Natl.Acad.Sci.U.S.A. 78 4354. PMID: 6945588.

Tanaka and Hidaka (1980) Hydrophobic regions function in calmodulin-enzyme(s) interactions. J.Biol.Chem. 255 11078. PMID: 6254958.

If you know of a relevant reference for W-7 hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for W-7 hydrochloride include:

Araki et al (2015) Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP. J Neurosci 85 173. PMID: 25569349.

Bonnefond et al (2015) Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation. J Biol Chem 20 535. PMID: 25627260.

Hou et al (2015) The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin. Apoptosis 13 e1002233. PMID: 26334624.

Yuan et al (2015) Protein kinase G-regulated production of H2S governs oxygen sensing. Sci Signal 8 ra37. PMID: 25900831.

Mukunda et al (2014) Dimerisation of the Drosophila odorant coreceptor Orco. Neuron 8 261. PMID: 25221476.

Chang et al (2013) Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis--a precancer condition. Psychopharmacology (Berl) 34 1096. PMID: 23349021.

Dai et al (2011) Phospholipase C, Ca2+, and calmodulin signaling are required for 5-HT2A receptor-mediated transamidation of Rac1 by transglutaminase. Front Cell Neurosci 213 403. PMID: 20717650.

Midkiff et al (2011) Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways. PLoS One 6 e25395. PMID: 21966518.

Long et al (2009) Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release. Carcinogenesis 284 8726. PMID: 19141616.

Yanes and Romero (2009) Dihydrotestosterone stimulates aldosterone secretion by H295R human adrenocortical cells. Mol Cell Endocrinol 303 50. PMID: 19428991.

Do you know of a great paper that uses W-7 hydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: W-7 hydrochloride, supplier, Calmodulin, antagonists, inhibitors, inhibits, myosin, light, chain, kinases, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, MLCK, Ca2+-calmodulin-dependent, phosphodiesterase, Tocris Bioscience, Calcium Binding Protein Modulator Antagonist products

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