Cat. No. 0369
Chemical Name: N-(6-Aminohexyl)-5-chloro-1-naphtha
Biological ActivityCalmodulin antagonist. Inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 μM) and myosin light chain kinase (IC50 = 51 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Asano et al (1989) Divergent pharmacological effects of three calmodulin antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W 7), chlorpromazine and calmidazolium, on isometric tension development and myosin light chain phosphorylation in intact bovine tracheal smooth muscle. J.Pharmacol.Exp.Ther. 251 764. PMID: 2810127.
Itoh and Hidaka (1984) Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase. J.Biochem. 96 1721. PMID: 6099352.
Hidaka et al (1981) N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc.Natl.Acad.Sci.U.S.A. 78 4354. PMID: 6945588.
Tanaka and Hidaka (1980) Hydrophobic regions function in calmodulin-enzyme(s) interactions. J.Biol.Chem. 255 11078. PMID: 6254958.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for W-7 hydrochloride include:
Yuan et al (2015) Protein kinase G-regulated production of H2S governs oxygen sensing. Sci Signal 8 ra37. PMID: 25900831.
Midkiff et al (2011) Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways. PLoS One 6 e25395. PMID: 21966518.
Yanes and Romero (2009) Dihydrotestosterone stimulates aldosterone secretion by H295R human adrenocortical cells. Mol Cell Endocrinol 303 50. PMID: 19428991.
Do you know of a great paper that uses W-7 hydrochloride from Tocris? If so please let us know.
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Keywords: W-7 hydrochloride, supplier, Calmodulin, antagonists, inhibitors, inhibits, myosin, light, chain, kinases, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, MLCK, Ca2+-calmodulin-dependent, phosphodiesterase, Tocris Bioscience, Calcium Binding Protein Modulator Antagonist products
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