Cat. No. 0368
Chemical Name: N-(6-Aminohexyl)-1-naphthalenesulfo
Biological ActivityCalmodulin antagonist (inhibits Ca2+-calmodulin dependent PDE with an IC50 of 240 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hidaka and Tanaka (1983) Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 102 185. PMID: 6139736.
Hidaka et al (1981) Activity-structure relationship of calmodulin antagonists. Naphthalenesulfonamide derivatives. Mol.Pharmacol. 20 571. PMID: 7329399.
Hidaka et al (1981) N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc.Natl.Acad.Sci.U.S.A. 78 4354. PMID: 6945588.
If you know of a relevant reference for W-5 hydrochloride please let us know.
Citations are publications that use Tocris products. Selected citations for W-5 hydrochloride include:
Long et al (2009) Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release. PLoS Biol 284 8726. PMID: 19141616.
Do you know of a great paper that uses W-5 hydrochloride from Tocris? If so please let us know.
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Keywords: W-5 hydrochloride, supplier, Calmodulin, antagonists, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, Tocris Bioscience, Calcium Binding Protein Modulator Antagonist products