Cat. No. 0757
Chemical Name: (3α,16α)-Eburnamenine-14-carboxylic acid ethyl ester
Biological ActivityPhosphodiesterase inhibitor, selective for PDE1 (IC50 = 21 μM). Also blocks voltage-gated Na+ channels.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Molnar and Erdo (1995) Vinpocetine is as potent as phenytoin to block voltage-gated Na+ channels in rat cortical neurons. Eur.J.Pharmacol. 273 303. PMID: 7737339.
Hagiwara et al (1984) Effect of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle. Biochem.Pharmacol. 33 453. PMID: 6322804.
Merck Index 12 10128.
If you know of a relevant reference for Vinpocetine please let us know.
Citations are publications that use Tocris products. Selected citations for Vinpocetine include:
Lee et al (2015) Vinpocetine inhibits Streptococcus pneumoniae-induced upregulation of mucin MUC5AC expression via induction of MKP-1 phosphatase in the pathogenesis of otitis media. EMBO Mol Med 194 5990. PMID: 25972475.
Do you know of a great paper that uses Vinpocetine from Tocris? If so please let us know.
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Keywords: Vinpocetine, supplier, PDE1, inhibitors, inhibits, Na+, channel, blockers, Phosphodiesterases, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products