(±)-Vesamicol hydrochloride

Cat. No. 0653

()-Vesamicol hydrochloride C17H25NO.HCl [120447-62-3]

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Alternative Name: AH 5183

Chemical Name: (±)-trans-2-(4-Phenylpiperidinyl)cyclohexanol hydrochloride

Biological Activity

Inhibitor of acetylcholine transport (Ki = 2 nM). Centrally active following systemic administration in vivo.

Technical Data

Soluble to 20 mM in ethanol and to 50 mM in DMSO with gentle warming
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Efange et al (1997) N-hydroxyalkyl derivatives of 3β-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters. J.Med.Chem. 40 3905. PMID: 9397171.

Kobayashi et al (1997) Effects of systemic administration of 2-(4-phenyl-piperidino)-cyclohexanol (vesamicol) and an organophosphate DDVP on the cholinergic system in brain regions of rats. Brain Res.Bull. 43 17. PMID: 9205789.

Varoqui and Erickson (1996) Active transport of acetylcholine by the human vesicular acetylcholine transporter. J.Biol.Chem. 271 27229. PMID: 8910293.

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Keywords: ()-Vesamicol hydrochloride, supplier, AH5183, inhibitors, inhibits, ACh, transport, Acetylcholine, Transporters, Monoamine, Neurotransmitter, Tocris Bioscience, Acetylcholine Transporter Inhibitor products

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Nicotinic ACh Scientific Review

Written by Susan Wonnacott

Nicotinic ACh Receptors Scientific Review

Our Nicotinic Acetylcholine Receptor review summarizes the structure and function of nAChR receptors, and the pharmacological ligands used to study them. Request copy or view PDF today.

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