Verapamil hydrochloride

Cat. No. 0654

Verapamil hydrochloride C27H38N2O4.HCl [152-11-4]

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Chemical Name: α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile hydrochloride

Biological Activity

L-type calcium channel blocker. Vasodilator, adrenergic antagonist.

Technical Data

M.Wt:
491.07
Formula:
C27H38N2O4.HCl
Solubility:
Soluble to 50 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
152-11-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Fleming et al (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 7 9. PMID: 21164513.

Ustunes et al (1996) Effects of verapamil on intimal thickening and vascular reactivity in the collared carotid artery of the rabbit. Br.J.Pharmacol. 118 1681. PMID: 8842432.

Ishibashi et al (1995) Block of P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons by diltiazem and verapamil. Brain Res. 695 88. PMID: 8574653.

Lacinova et al (1995) Interaction of RO-40-5967 and verapamil with the stably expressed α1-subunit of the cardiac L-type calcium channel. J.Pharmacol.Exp.Ther. 274 54. PMID: 7616442.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Verapamil hydrochloride include:

Xia et al (2011) Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. Toxicol Appl Pharmacol 252 250. PMID: 21362439.

Szikra et al (2009) Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels. PLoS One 4 e6723. PMID: 19696927.

Do you know of a great paper that uses Verapamil hydrochloride from Tocris? If so please let us know.

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Keywords: Verapamil hydrochloride, supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, vasodilator, Tocris Bioscience, Voltage-gated Calcium Channel (CaV) Blocker products

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