Verapamil hydrochloride

Cat. No. 0654

Verapamil hydrochloride C27H38N2O4.HCl [152-11-4]

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Chemical Name: α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile hydrochloride

Biological Activity

L-type calcium channel blocker. Vasodilator, adrenergic antagonist.

Technical Data

Soluble to 50 mM in water
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Fleming et al (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 7 9. PMID: 21164513.

Ustunes et al (1996) Effects of verapamil on intimal thickening and vascular reactivity in the collared carotid artery of the rabbit. Br.J.Pharmacol. 118 1681. PMID: 8842432.

Ishibashi et al (1995) Block of P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons by diltiazem and verapamil. Brain Res. 695 88. PMID: 8574653.

Lacinova et al (1995) Interaction of RO-40-5967 and verapamil with the stably expressed α1-subunit of the cardiac L-type calcium channel. J.Pharmacol.Exp.Ther. 274 54. PMID: 7616442.

If you know of a relevant reference for Verapamil hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for Verapamil hydrochloride include:

Azab et al (2015) Binding of αherpesvirus Glycoprotein H to Surface α4β1-Integrins Activates Calcium-Signaling Pathways and Induces Phosphatidylserine Exposure on the Plasma Membrane. FEMS Immunol Med Microbiol 6. PMID: 26489864.

Fransen et al (2015) Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments. Cereb Cortex 10 e0121634. PMID: 25803863.

Chang et al (2013) Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis--a precancer condition. PLoS One 34 1096. PMID: 23349021.

Xia et al (2011) Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. Toxicol Appl Pharmacol 252 250. PMID: 21362439.

Szikra et al (2009) Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels. PLoS One 4 e6723. PMID: 19696927.

Wieland et al (2006) Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels. Carcinogenesis 47 296. PMID: 16831218.

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Keywords: Verapamil hydrochloride, supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, vasodilator, Tocris Bioscience, Voltage-gated Calcium Channel (CaV) Blocker products

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