Cat. No. 0425
Chemical Name: 5-Bromo-6-(2-imidazolin-2-ylamino)q
Biological ActivityFull α2 adrenergic agonist. Centrally active following systemic administration in vivo. Also available as part of the α2-Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™. Water soluble salt version UK 14,304 tartrate (Cat. No. 2466) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Chopin et al (1999) Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J.Pharmacol.Exp.Ther. 288 798. PMID: 9918591.
Macdonald et al (1997) Gene trageting - homing in on α2-adrenoceptor-subtype function. TiPS 18 211. PMID: 9227000.
Andorn et al (1988) Specific [3H]UK-14,304 binding in human cortex occurs at multiple high affinity states with α2-adrenergic selectivity and different affinities for GTP. Life Sci. 43 1805. PMID: 2904634.
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Citations are publications that use Tocris products. Selected citations for UK 14,304 include:
Jasmin et al (2002) The NK1 receptor mediates both the hyperalgesia and the resistance to morphine in mice lacking noradrenaline. Proc Natl Acad Sci U S A 99 1029. PMID: 11805341.
Do you know of a great paper that uses UK 14,304 from Tocris? If so please let us know.
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