UK 14,304

Cat. No. 0425

UK 14,304 C11H10BrN5 [59803-98-4]

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Chemical Name: 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline

Biological Activity

Full α2 adrenergic agonist. Centrally active following systemic administration in vivo. Also available as part of the α2-Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™. Water soluble salt version UK 14,304 tartrate (Cat. No. 2466) also available.

Technical Data

M.Wt:
292.14
Formula:
C11H10BrN5
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at RT
CAS No:
59803-98-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Chopin et al (1999) Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J.Pharmacol.Exp.Ther. 288 798. PMID: 9918591.

Macdonald et al (1997) Gene trageting - homing in on α2-adrenoceptor-subtype function. TiPS 18 211. PMID: 9227000.

Andorn et al (1988) Specific [3H]UK-14,304 binding in human cortex occurs at multiple high affinity states with α2-adrenergic selectivity and different affinities for GTP. Life Sci. 43 1805. PMID: 2904634.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for UK 14,304 include:

Sadeghi et al (2015) μ-Opioid receptor activation and noradrenaline transport inhibition by tapentadol in rat single locus coeruleus neurons. J Pharmacol Exp Ther 172 460. PMID: 24372103.

Tunstall et al (2011) MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. J Neurosci 336 127. PMID: 20959363.

Jasmin et al (2002) The NK1 receptor mediates both the hyperalgesia and the resistance to morphine in mice lacking noradrenaline. Proc Natl Acad Sci U S A 99 1029. PMID: 11805341.

Do you know of a great paper that uses UK 14,304 from Tocris? If so please let us know.

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Keywords: UK 14,304, supplier, α2-adrenoceptor, alpha2-adrenoceptors, a2-adrenoceptors, agonists, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, Receptors, UK14304, Tocris Bioscience, Adrenergic α2 Receptor Agonist products

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