Cat. No. 0498
Chemical Name: cis-(±)-3,4-Dichloro-N-methyl-N-[2-(
Biological Activityκ-opioid agonist and anticonvulsant. Perhaps acts as an NMDA antagonist.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
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References are publications that support the products' biological activity.
Sethy and Sage (1992) Modulation of release of acetylcholine from the striatum by a proposed excitatory amino acid antagonist U-54494A: comparison with known antagonists, diazepam and phenytoin. Neuropharmacology 31 111. PMID: 1348110.
Proietti et al (1991) In vitro depressant effects of U-54494A, an anticonvulsant related to kappa opioids in the hippocampus. Neuropharmacology 30 637. PMID: 1656303.
Voigtlander et al (1987) U-54494A: a unique anticonvulsant related to kappa opioid agonists. J.Pharmacol.Exp.Ther. 243 542. PMID: 2824750.
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Citations are publications that use Tocris products.
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Keywords: U-54494A hydrochloride, supplier, agonists, κ-opioid, kappa-opioid, KOP, Receptors, OP2, Tocris Bioscience, κ Opioid Receptor Agonist products