U-54494A hydrochloride

Cat. No. 0498

U-54494A hydrochloride C18H24Cl2N2O.HCl [112465-94-8]

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Chemical Name: cis-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzamide hydrochloride

Biological Activity

κ-opioid agonist and anticonvulsant. Perhaps acts as an NMDA antagonist.

Technical Data

M.Wt:
391.77
Formula:
C18H24Cl2N2O.HCl
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at RT
CAS No:
112465-94-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service
Safety Data Sheet: View Safety Data Sheet

Sethy and Sage (1992) Modulation of release of acetylcholine from the striatum by a proposed excitatory amino acid antagonist U-54494A: comparison with known antagonists, diazepam and phenytoin. Neuropharmacology 31 111. PMID: 1348110.

Proietti et al (1991) In vitro depressant effects of U-54494A, an anticonvulsant related to kappa opioids in the hippocampus. Neuropharmacology 30 637. PMID: 1656303.

Voigtlander et al (1987) U-54494A: a unique anticonvulsant related to kappa opioid agonists. J.Pharmacol.Exp.Ther. 243 542. PMID: 2824750.

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Keywords: U-54494A hydrochloride, supplier, agonists, κ-opioid, kappa-opioid, KOP, Receptors, OP2, Tocris Bioscience, κ Opioid Receptor Agonist products

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