Cat. No. 0496
Chemical Name: trans-(-)-3,4-Dichloro-N-methyl-N-[
Biological ActivityMore active enantiomer of (±)-U-50488 (Cat. No. 0495). (+)-U-50488 hydrochloride (Cat. No. 0471) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Zhu et al (1998) Agonist-induced desensitization and down-regulation of the human kappa opioid receptor expressed in chinese hamster ovary cells. J.Pharmacol.Exp.Ther. 285 28. PMID: 9535991.
Morrone et al (1993) Withdrawal contractures of guinea-pig isolated ileum after acute activation of κ opioid receptors. Br.J.Pharmacol. 109 48. PMID: 8388301.
Reddy and Bhargava (1993) Effect of chronic administration of U-50,488H, a kappa opioid receptor agonist on central dopamine (D2) receptors of the rat. Eur.J.Pharmacol. 235 23. PMID: 8390939.
De Costa et al (1987) Synthesis and absolute configuration of optically pure enantiomers of a κ-opioid receptor selective antagonist. FEBS Lett. 223 335. PMID: 2822490.
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Keywords: (-)-U-50488 hydrochloride, supplier, selective, κ-opioid, kappa-opioid, agonists, KOP, Receptors, OP2, Tocris Bioscience, κ Opioid Receptor Agonist products