ω-Conotoxin MVIIC

Cat. No. 1084

w-Conotoxin MVIIC Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-NH2 (Disulfide bridges: 1 - 16, 8 - 20, 15 - 26)

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Biological Activity

Peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.

Licensing Information

Sold under license from the University of Utah.

Technical Data

M.Wt:
2749
Formula:
C106H178N40O32S7
Sequence:
CKGKGAPCRKTMYDCCSGSCGRRGKC

(Modifications: Disulfide bridge between 1 - 16, 8 - 20, 15 - 26, Cys-26 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
147794-23-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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McDonough et al (1996) Inhibition of Ca2+ channels in rat central and peripheral neurons by ω-conotoxin MVIIC. J.Neurosci. 16 2612. PMID: 8786437.

Hillyard et al (1992) A new conus peptide ligand for mammalian presynaptic Ca2+ channels. Neuron 9 69. PMID: 1352986.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for ω-Conotoxin MVIIC include:

Pan et al (2014) σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons. PLoS One 350 290. PMID: 24891452.

Maier et al (2010) Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation. J Biol Chem 285 35606. PMID: 20826795.

Haeberle et al Swelling-activated Ca2+ channels trigger Ca2+ signals in Merkel cells. Nat Commun 3 e1750. PMID: 18454189.

Do you know of a great paper that uses ω-Conotoxin MVIIC from Tocris? If so please let us know.

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Keywords: w-Conotoxin MVIIC, supplier, Ca2+, channel, blockers, N-type, P-type, Q-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, omega-Conotoxin, ω-conotoxin, MVIIC, neurotoxins, Tocris Bioscience, Voltage-gated Calcium Channel (CaV) Blocker products

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