(R)-Baclofen

Cat. No. 0796

(R)-Baclofen C10H12ClNO2 [69308-37-8]

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Alternative Name: STX 209

Chemical Name: (R)-4-Amino-3-(4-chlorophenyl)butanoic acid

Biological Activity

More active enantiomer of (RS)-Baclofen (Cat. No. 0417), a selective GABAB agonist.

Technical Data

M.Wt:
213.66
Formula:
C10H12ClNO2
Solubility:
Soluble to 20 mM in water with gentle warming
Purity:
>99 %
Storage:
Store at RT
CAS No:
69308-37-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Hong et al (1991) Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat. Eur.J.Pharmacol. 196 267. PMID: 1654254.

Falch et al (1986) Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations. J.Neurochem. 47 898. PMID: 3016189.

If you know of a relevant reference for (R)-Baclofen please let us know.

Citations are publications that use Tocris products. Selected citations for (R)-Baclofen include:

Bragina et al (2015) Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals. Front Cell Neurosci 9 345. PMID: 26388733.

Kirwan et al (2015) Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro. J Pharmacol Exp Ther 142 3178. PMID: 26395144.

Wang et al (2015) Neuronal γ-aminobutyric acid (GABA) type A receptors undergo cognate ligand chaperoning in the endoplasmic reticulum by endogenous GABA. Mol Cell Neurosci 9 188. PMID: 26041994.

Zhang et al (2015) GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Front Cell Neurosci 5 10468. PMID: 26020477.

Xia et al (2014) Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons. PLoS One 9 e100968. PMID: 24971996.

Hensler et al (2012) GABAB receptor-positive modulators: brain region-dependent effects. J Pharmacol Exp Ther 340 19. PMID: 21954301.

Pacey et al (2011) Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome. Sci Rep 338 897. PMID: 21636656.

Bartoi et al (2010) GABAB receptor constituents revealed by tandem affinity purification from transgenic mice. J Biol Chem 285 20625. PMID: 20406808.

Lobb et al (2010) A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons. J Neurophysiol 104 403. PMID: 20445035.

Piqueras and Martínez (2004) Peripheral GABAB agonists stimulate gastric acid secretion in mice. Br J Pharmacol 142 1038. PMID: 15210585.

Do you know of a great paper that uses (R)-Baclofen from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: (R)-Baclofen, supplier, Selective, GABAB, agonists, Receptors, STX209, Tocris Bioscience, GABAB Receptor Agonist products

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