AG 556

Cat. No. 0616

AG 556 C20H20N2O3 [133550-41-1]

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Alternative Name: Tyrphostin AG 556

Chemical Name: (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-2-propenamide

Biological Activity

Epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 1.1 μM). Selective over ErbB2 (IC50 > 500 μM).

Technical Data

M.Wt:
336.39
Formula:
C20H20N2O3
Solubility:
Soluble to 30 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
133550-41-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Gamett et al (1997) Secondary dimerization between members of the epidermal growth factor receptor family. J.Biol.Chem. 272 12052. PMID: 9115272.

Gazit et al (1991) Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896. PMID: 1676428.

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