AG 494

Cat. No. 0619

AG 494 C16H12N2O3 [133550-35-3]

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Chemical Name: (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-2-propenamide

Biological Activity

Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC50 = 0.7 μM). Selective over ErbB2, PDGFR and insulin receptor kinase (IC50 values are 42, 6 and > 100 μM respectively).

Technical Data

M.Wt:
280.28
Formula:
C16H12N2O3
Solubility:
Soluble to 5 mM in ethanol and to 50 mM in DMSO
Storage:
Desiccate at +4°C
CAS No:
133550-35-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Tomlins et al (2005) Cross-talk between the calcium-sensing receptor and the epidermal growth factor receptor in Rat-1 fibroblasts. Exp.Cell Res. 308 439. PMID: 15950968.

Ben-Bassat et al (1999) Tyrphostins that suppress the growth of human papilloma virus 16-immortalized human keratinocytes. J.Pharmacol.Exp.Ther. 290 1442. PMID: 10454524.

Gazit et al (1991) Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896. PMID: 1676428.

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Keywords: AG 494, supplier, Potent, EGFR, kinase, inhibitors, inhibits, Epidermal, Growth, Factors, Receptors, ErbB, Her, Tyrosine, Kinases, RTKs, AG494, Tocris Bioscience, EGFR Inhibitor products

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