AG 555

Cat. No. 0618

AG 555 C19H18N2O3 [133550-34-2]

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Alternative Name: Tyrphostin AG 555

Chemical Name: (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)-2-propenamide

Biological Activity

Potent epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 0.7 μM) that displays 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Induce G1 growth arrest selectively in transformed cells (IC50 values are 6.4 and 9.4 μM in HPV16-immortalized and normal keratinocytes respectively).

Technical Data

M.Wt:
322.36
Formula:
C19H18N2O3
Solubility:
Soluble to 30 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
133550-34-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Ben-Bassat et al (1999) Tyrphostins that suppress the growth of human papilloma virus 16-immortalized human keratinocytes. J.Pharmacol.Exp.Ther. 290 1442. PMID: 10454524.

Levitzki and Gazit (1995) Tyrosine kinase inhibition: an approach to drug development. Science 267 1782. PMID: 7892601.

Gazit et al (1991) Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896. PMID: 1676428.

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