Tyrphostin B44, (-) enantiomer

Cat. No. 0578

Tyrphostin B44, (-) enantiomer C18H16N2O3 [133550-32-0]

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Chemical Name: (R)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide

Biological Activity

Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC50 = 0.4 μM), more active than the (+) enantiomer (Cat. No. 0579). Selective over ErbB2.

Technical Data

M.Wt:
308.34
Formula:
C18H16N2O3
Solubility:
Soluble to 30 mM in DMSO
Storage:
Desiccate at +4°C
CAS No:
133550-32-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Gazit et al (1991) Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896. PMID: 1676428.

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