Cat. No. 1082
Chemical Name: 1-(4'-Aminophenyl)-3,5-dihydro-7,8-d
Biological ActivityNovel, selective non-competitive AMPA antagonist. Highly potent, long-acting anticonvulsant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
De Sarro et al (1999) Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats. Eur.J.Pharmacol. 368 149. PMID: 10193651.
De Sarro et al (1999) Anticonvulsant activity and plasma level of 2,3-benzodiazepin-4-ones (CFMs) in genetically epilepsy-prone rats. Pharmacol.Biochem.Behav. 63 621. PMID: 10462191.
Chimirri et al (1997) 1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists. J.Med.Chem. 40 1258. PMID: 9111300.
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Citations are publications that use Tocris products. Selected citations for CFM-2 include:
Nygaard et al (2015) Melanoma brain colonization involves the emergence of a brain-adaptive phenotype. Proc Natl Acad Sci U S A 1 82. PMID: 25593989.
Rzeski et al (2001) Glutamate antagonists limit tumor growth. J Pharmacol Exp Ther 98 6372. PMID: 11331750.
Do you know of a great paper that uses CFM-2 from Tocris? If so please let us know.
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Keywords: CFM-2, supplier, Non-competitive, AMPA, antagonists, Glutamate, Receptors, iGlur, Ionotropic, Tocris Bioscience, AMPA Receptor Antagonist products