CFM-2

Cat. No. 1082

CFM-2 C17H17N3O3 [178616-26-7]

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Chemical Name: 1-(4'-Aminophenyl)-3,5-dihydro-7,8-dimethoxy-4H-2,3-benzodiazepin-4-one

Biological Activity

Novel, selective non-competitive AMPA antagonist. Highly potent, long-acting anticonvulsant.

Technical Data

M.Wt:
311.34
Formula:
C17H17N3O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
178616-26-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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De Sarro et al (1999) Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats. Eur.J.Pharmacol. 368 149. PMID: 10193651.

De Sarro et al (1999) Anticonvulsant activity and plasma level of 2,3-benzodiazepin-4-ones (CFMs) in genetically epilepsy-prone rats. Pharmacol.Biochem.Behav. 63 621. PMID: 10462191.

Chimirri et al (1997) 1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists. J.Med.Chem. 40 1258. PMID: 9111300.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for CFM-2 include:

Nygaard et al (2015) Melanoma brain colonization involves the emergence of a brain-adaptive phenotype. Proc Natl Acad Sci U S A 1 82. PMID: 25593989.

Rzeski et al (2001) Glutamate antagonists limit tumor growth. J Pharmacol Exp Ther 98 6372. PMID: 11331750.

Do you know of a great paper that uses CFM-2 from Tocris? If so please let us know.

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Keywords: CFM-2, supplier, Non-competitive, AMPA, antagonists, Glutamate, Receptors, iGlur, Ionotropic, Tocris Bioscience, AMPA Receptor Antagonist products

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