(+)-SK&F 10047 hydrochloride
Cat. No. 1079
Chemical Name: (2S,6S,11S)-1,2,3,4,5,6-Hexahydro-6
Biological ActivityPrototypical σ1 receptor agonist. Behaviorally active in animal models of memory and stress.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kamei et al (1996) (+)-SKF-10,047 and dextromethorphan ameliorate conditioned fear stress via dopaminergic systems linked to phenytoin-regulated σ1 sites. Eur.J.Pharmacol. 309 149. PMID: 8874133.
Matsuno et al (1995) Involvement of σ1 receptor in (+)-N-allylnormetazocine-stimulated hippocampal cholinergic functions in rats. Brain Res. 690 200. PMID: 8535837.
Walker et al (1990) Sigma receptors: biology and function. Pharmacol.Rev. 42 355. PMID: 1964225.
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Citations are publications that use Tocris products. Selected citations for (+)-SK&F 10047 hydrochloride include:
Kasaharaa et al (2016) The σ1 receptor regulates accumulation of GM1 ganglioside-enriched autophagosomes in astrocytes Neuroscience 340 176. PMID: 27815022.
Rodríguez-Muñoz et al (2015) The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders. Int J Neuropsychopharmacol 6 35458. PMID: 26461475.
Sánchez-Blázquez et al (2014) The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. PLoS One 17 1943. PMID: 24485144.
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