(+)-SK&F 10047 hydrochloride

Cat. No. 1079

(+)-SK&F 10047 hydrochloride C17H23NO.HCl [133005-41-1]

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Chemical Name: (2S,6S,11S)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(2-propenyl)-2,6-methano-3-benzazocin-8-ol hydrochloride

Biological Activity

Prototypical σ1 receptor agonist. Behaviorally active in animal models of memory and stress.

Technical Data

M.Wt:
293.84
Formula:
C17H23NO.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
133005-41-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Kamei et al (1996) (+)-SKF-10,047 and dextromethorphan ameliorate conditioned fear stress via dopaminergic systems linked to phenytoin-regulated σ1 sites. Eur.J.Pharmacol. 309 149. PMID: 8874133.

Matsuno et al (1995) Involvement of σ1 receptor in (+)-N-allylnormetazocine-stimulated hippocampal cholinergic functions in rats. Brain Res. 690 200. PMID: 8535837.

Walker et al (1990) Sigma receptors: biology and function. Pharmacol.Rev. 42 355. PMID: 1964225.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for (+)-SK&F 10047 hydrochloride include:

Rodríguez-Muñoz et al (2015) The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders. Int J Neuropsychopharmacol 6 35458. PMID: 26461475.

Sánchez-Blázquez et al (2014) The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. PLoS One 17 1943. PMID: 24485144.

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