(+)-SK&F 10047 hydrochloride

Cat. No. 1079

(+)-SK&F 10047 hydrochloride C17H23NO.HCl [133005-41-1]

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Chemical Name: (2S,6S,11S)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(2-propenyl)-2,6-methano-3-benzazocin-8-ol hydrochloride

Biological Activity

Prototypical σ1 receptor agonist. Behaviorally active in animal models of memory and stress.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>98 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Kamei et al (1996) (+)-SKF-10,047 and dextromethorphan ameliorate conditioned fear stress via dopaminergic systems linked to phenytoin-regulated σ1 sites. Eur.J.Pharmacol. 309 149. PMID: 8874133.

Matsuno et al (1995) Involvement of σ1 receptor in (+)-N-allylnormetazocine-stimulated hippocampal cholinergic functions in rats. Brain Res. 690 200. PMID: 8535837.

Walker et al (1990) Sigma receptors: biology and function. Pharmacol.Rev. 42 355. PMID: 1964225.

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