Tempol

Cat. No. 3082

Tempol C9H18NO2 [2226-96-2]

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Chemical Name: 1-Oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine

Biological Activity

Superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects.

Technical Data

M.Wt:
172.24
Formula:
C9H18NO2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
2226-96-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Deng-Bryant et al (2008) Neuroprotective effect of tempol, a catalytic scavenger of peroxynitrite-derived free radicals, in a mouse traumatic brain injury model. J.Cereb.Blood Flow Metab. 28 1114. PMID: 18319733.

Francis and Sehgal (2006) The superoxide scavenger TEMPOL induces urokinase receptor (uPAR) expression in human prostate cancer cells. Mol.Cancer 5 21. PMID: 16756681.

Khattab (2006) TEMPOL, a membrane-permeable radical scavenger, attenuates peroxynitrite- and superoxide anion-enhanced carrageenan-induced paw edema and hyperalgesia: a key role for superoxide anion. EurJ.Pharmacol. 548 167.

If you know of a relevant reference for Tempol please let us know.

Citations are publications that use Tocris products. Selected citations for Tempol include:

Tomasovic et al (2015) Sestrin 2 Regulates PDGF Receptor β (PDGFRβ) Expression by Modulating Proteasomal and Nrf2 Transcription Factor Functions. Brain Res NULL. PMID: 25716320.

Senturk et al (2014) p53ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state. Proc Natl Acad Sci U S A 111 E3287. PMID: 25074920.

Nesuashvili et al (2013) Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels. Mol Pharmacol 83 1007. PMID: 23444014.

Ruparel et al (2012) Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. J Biol Chem 153 2031. PMID: 22633978.

Valente et al (2012) Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18. Am J Physiol Heart Circ Physiol 303 H282. PMID: 22636674.

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Keywords: Tempol, supplier, Superoxide, scavenger, antioxidant, Tocris Bioscience, Antioxidant products

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