Nafamostat mesylate

Cat. No. 3081

Nafamostat mesylate C19H17N5O2.2CH4O3S [82956-11-4]

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Chemical Name: 4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate

Biological Activity

Broad spectrum serine protease inhibitor. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma.

Technical Data

M.Wt:
539.59
Formula:
C19H17N5O2.2CH4O3S
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
82956-11-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Chen et al (2006) Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma. J.Allergy Clin.Immunol. 118 105. PMID: 16815145.

Mori et al (2003) Nafamostat mesilate is an extremely potent inhibitor of human tryptase. J.Pharmacol.Sci. 92 420. PMID: 12939527.

Sendo et al (2003) A potent tryptase inhibitor nafamostat mesilate dramatically suppressed pulmonary dysfunction induced in rats by a radiographic contrast medium. Br.J.Pharmacol. 138 959. PMID: 12642398.

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Keywords: Nafamostat mesylate, supplier, Serine, protease, inhibitors, inhibits, Proteases, Proteinases, Tocris Bioscience, Other Protease Inhibitor products

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