TTNPB

Cat. No. 0761

TTNPB C24H28O2 [71441-28-6]

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Alternative Name: Ro 13-7410

Chemical Name: 4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid

Biological Activity

Extremely potent analog of retinoic acid, selective for the retinoic acid receptor (RAR) subtype. Enhances reprogramming efficiency in chemically induced pluripotent stem cells (CiPSCs).

Technical Data

M.Wt:
348.48
Formula:
C24H28O2
Solubility:
Soluble to 10 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
71441-28-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Hou et al (2013) Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science 341 651. PMID: 23868920.

Minucci et al (1996) Retinoid X receptor-selective ligands produce malformations in Xenopus embryos. Proc.Natl.Acad.Sci.U.S.A. 93 1803. PMID: 8700839.

Loeliger et al (1980) Arotinoids, a new class of highly active retinoids. Eur.J.Med.Chem.-Chim.Ther. 15 9.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for TTNPB include:

Chronopoulos et al (2016) ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion Nature Communications 7 12630. PMID: 27600527.

Francipane and Lagasse (2015) The lymph node as a new site for kidney organogenesis. Stem Cells Transl Med 4 295. PMID: 25646529.

Thomas and Henry (2014) Retinoic acid regulation by CYP26 in vertebrate lens regeneration. Br J Pharmacol 386 291. PMID: 24384390.

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Keywords: TTNPB, supplier, Retinoic, acid, analogs, agonists, RAR, Receptors, Ro, 13-7410, Tocris Bioscience, Retinoic Acid Receptor Agonist products

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