Vigabatrin

Cat. No. 0808

Vigabatrin C6H11NO2
 [60643-86-9]

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Alternative Name: (±)-γ-Vinyl GABA

Chemical Name: 4-Aminohexenoic acid

Biological Activity

Selective GABA-T (transaminase) inhibitor. Anticonvulsant.

Technical Data

M.Wt:
129.16
Formula:
C6H11NO2
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
60643-86-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Schmid et al (1996) Vigabatrin modulates benzodiazepine receptor activity in vivo: a positron emission tomography study in baboon. J.Pharmacol.Exp.Ther. 276 977. PMID: 8786578.

Halonen et al (1991) Effects of vigabatrin (γ-vinyl GABA) on neurotransmission-related amino acids and on GABA and benzodiazepine receptor binding in rats. Epilepsia 32 242. PMID: 1672276.

Larsson et al (1986) Differential effect of gamma-vinyl GABA and valproate on GABA transaminase from cultured neurones and astrocytes. Neuropharmacology 25 617. PMID: 3092125.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Vigabatrin include:

Héja et al (2009) Glutamate uptake triggers transporter-mediated GABA release from astrocytes. Stem Cells Dev 4 e7153. PMID: 19777062.

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Keywords: Vigabatrin, supplier, GABA-T, inhibitors, inhibits, GABA-Transferase, Transferases, GABA, GABAA, GABAC, Receptors, GABAB, ()-γ-Vinyl, ()-gamma-Vinyl, Tocris Bioscience, Miscellaneous GABA products

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