Cat. No. 3547
Alternative Names: 5-Hydroxytryptamine, 5-HT
Chemical Name: 3-(2-Aminoethyl)-1H-indol-5-ol hydrochloride
Biological ActivityEndogenous agonist at 5-HT receptors and endogenous substrate for 5-HT transporters. Neurotransmitter that has roles in regulation of mood, emesis, sexuality, sleep and appetite in vivo. Caged serotonin is also available (Cat.No. 3991).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Barnes and Sharp (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38 1083. PMID: 10462127.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Serotonin hydrochloride include:
Bocchio et al (2015) Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala. Neuropsychopharmacology 40 3015. PMID: 26052039.
Gerhold et al (2015) Pronociceptive and antinociceptive effects of buprenorphine in the spinal cord dorsal horn cover a dose range of four orders of magnitude. J Neurosci 35 9580. PMID: 26134641.
Daftary et al (2012) Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala. Neuroscience 224 125. PMID: 22917617.
Robery et al (2011) Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research. PLoS One 6 e24439. PMID: 21931717.
Rawls et al (2010) 5-HT1A-like receptor activation inhibits abstinence-induced methamphetamine withdrawal in planarians. Neurosci Lett 484 113. PMID: 20709144.
View Related Products by Target
View Related Products by Product Action
Keywords: Serotonin hydrochloride, supplier, Endogenous, 5-HT, receptors, agonists, Non-selective, Tocris Bioscience, Non-selective 5-HT Agonist products