Serotonin hydrochloride

Cat. No. 3547

Serotonin hydrochloride C10H12N2O.HCl [153-98-0]

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Alternative Names: 5-Hydroxytryptamine, 5-HT

Chemical Name: 3-(2-Aminoethyl)-1H-indol-5-ol hydrochloride

Biological Activity

Endogenous agonist at 5-HT receptors and endogenous substrate for 5-HT transporters. Neurotransmitter that has roles in regulation of mood, emesis, sexuality, sleep and appetite in vivo. Caged serotonin is also available (Cat.No. 3991).

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>99 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Barnes and Sharp (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38 1083. PMID: 10462127.

If you know of a relevant reference for Serotonin hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for Serotonin hydrochloride include:

Bocchio et al (2015) Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala. Neuropsychopharmacology 40 3015. PMID: 26052039.

Gerhold et al (2015) Pronociceptive and antinociceptive effects of buprenorphine in the spinal cord dorsal horn cover a dose range of four orders of magnitude. J Neurosci 35 9580. PMID: 26134641.

Haynes et al (2015) A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster. BMC Vet Res 4. PMID: 25564731.

Bracha et al (2013) The expression and role of serotonin receptor 5HTR2A in canine osteoblasts and an osteosarcoma cell line. Am J Physiol Regul Integr Comp Physiol 9 251. PMID: 24330646.

Daftary et al (2012) Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala. Neuroscience 224 125. PMID: 22917617.

Robery et al (2011) Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research. PLoS One 6 e24439. PMID: 21931717.

Rawls et al (2010) 5-HT1A-like receptor activation inhibits abstinence-induced methamphetamine withdrawal in planarians. Neurosci Lett 484 113. PMID: 20709144.

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Keywords: Serotonin hydrochloride, supplier, Endogenous, 5-HT, receptors, agonists, Non-selective, Tocris Bioscience, Non-selective 5-HT Agonist products

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