LY 334370 hydrochloride

Cat. No. 3079

LY 334370 hydrochloride C21H22FN3O.HCl [199673-74-0]

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Chemical Name: 4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide hydrochloride

Biological Activity

Selective 5-HT1F receptor agonist (Ki values are 1.87, 16.4, > 100 (IC50), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC50) and 3250 nM for 5-HT1F, 5-HT1A, 5-HT4, 5-HT1E, 5-HT1B, 5-HT1D, 5-HT2B, 5-HT2A, 5-HT7, 5-HT6 and 5-HT2C receptors respectively). Displays antimigraine effects.

Licensing Information

Sold under license from Eli Lilly and company

Technical Data

M.Wt:
387.88
Formula:
C21H22FN3O.HCl
Solubility:
Soluble to 25 mM in water with gentle warming and to 25 mM in DMSO with gentle warming
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
199673-74-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Wainscott et al (2005) [H3]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties. Naunyn-Schmied.Arch.Pharmacol. 371 169.

Shepheard et al (1999) Possible antimigraine mechanisms of action of the 5-HT1F receptor agonist LY334370. Cephalalgia 19 851. PMID: 10668103.

Dupuis et al (1998) G-protein activationat 5-HT1A receptors by the 5-ht1F ligand LY334370 in guinea-pig brain sections and recombinant cell lines. Br.J.Pharmacol. 124 283. PMID: 9641544.

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Citations are publications that use Tocris products. Selected citations for LY 334370 hydrochloride include:

Garrett et al (2014) Agonism of the 5-hydroxytryptamine 1F receptor promotes mitochondrial biogenesis and recovery from acute kidney injury. J Pharmacol Exp Ther 350 257. PMID: 24849926.

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Keywords: LY 334370 hydrochloride, supplier, Selective, 5-HT1F, agonists, Serotonin, Receptors, LY334370, hydrochloride, Tocris Bioscience, 5-HT1F Receptor Agonist products

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