LY 272015 hydrochloride
Cat. No. 3077
Chemical Name: 1-[(3,4-Dimethoxyphenyl)methy]-2,3,
Biological ActivityHigh affinity 5-HT2B receptor antagonist that displays selectivity over 5-HT2A and 5-HT2C receptors (Ki values are 0.75, 21.63 and 28.7 nM for 5-HT2B, 5-HT2C and 5-HT2A receptors respectively). Orally active.
Licensing InformationSold under license from Eli Lilly and company
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Niebert et al (2011) Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. PLoS One 6 e21395. PMID: 21789169.
Sevoz-Couche et al (2000) In vivo modulation of vagal-identified dorsal medullary neurones by activation of different 5-Hydroxytryptamine2 receptors in rat. Br.J.Pharmacol. 131 1445. PMID: 11090119.
Cohen et al (1996) LY272015, a potent, selective and orally active 5-HT2B receptor antagonist. J.Serotonin Res. 3 131.
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Citations are publications that use Tocris products. Selected citations for LY 272015 hydrochloride include:
Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. PLoS One 3 e00103. PMID: 25692021.
Soll et al (2012) Expression of serotonin receptors in human hepatocellular cancer. Clin Cancer Res 18 5902. PMID: 23087410.
Niebert et al (2011) Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. J Pharmacol Exp Ther 6 e21395. PMID: 21789169.
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