SM-21 maleate

Cat. No. 0751

SM-21 maleate C18H24ClNO3.C4H4O4 [155059-42-0]

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Chemical Name: (±)-Tropanyl 2-(4-chlorophenoxy)butanoate maleate

Biological Activity

Potent and selective σ2 antagonist with central effects following systemic administration. Causes increased release of acetylcholine at central muscarinic synapses. Potent analgesic (efficacy comparable to morphine) and nootropic agent.

Technical Data

M.Wt:
453.92
Formula:
C18H24ClNO3.C4H4O4
Solubility:
Soluble to 25 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
155059-42-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Matsumoto and Mack (2001) (±)-SM 21 attenuates the convulsive and locomotor stimulatory effects of cocaine in mice. Eur.J.Pharmacol. 417 R1. PMID: 11301071.

Ghelardini et al (2000) Pharmacological identification of SM-21, the novel σ2 antagonist. Pharmacol.Biochem.Behav. 67 659. PMID: 11164098.

Ghelardini et al (1997) Antinociceptive profile of 3-α-tropanyl-(2-Cl)-acid phenoxybutyrate (SM-21): a novel analgesic with a presynaptic cholinergic mechanism of action. J.Pharmacol.Exp.Ther. 282 430. PMID: 9223584.

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Keywords: SM-21 maleate, supplier, Selective, σ2, sigma2, receptors, antagonists, Presynaptic, cholinergic, modulators, Muscarinic, Acetylcholine, release, Nicotinic, nAChR, Tocris Bioscience, Other Acetylcholine Modulator products

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