Cat. No. 0751
Chemical Name: (±)-Tropanyl 2-(4-chlorophenoxy)butanoate maleate
Biological ActivityPotent and selective σ2 antagonist with central effects following systemic administration. Causes increased release of acetylcholine at central muscarinic synapses. Potent analgesic (efficacy comparable to morphine) and nootropic agent.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Matsumoto and Mack (2001) (±)-SM 21 attenuates the convulsive and locomotor stimulatory effects of cocaine in mice. Eur.J.Pharmacol. 417 R1. PMID: 11301071.
Ghelardini et al (2000) Pharmacological identification of SM-21, the novel σ2 antagonist. Pharmacol.Biochem.Behav. 67 659. PMID: 11164098.
Ghelardini et al (1997) Antinociceptive profile of 3-α-tropanyl-(2-Cl)-acid phenoxybutyrate (SM-21): a novel analgesic with a presynaptic cholinergic mechanism of action. J.Pharmacol.Exp.Ther. 282 430. PMID: 9223584.
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Keywords: SM-21 maleate, supplier, Selective, σ2, sigma2, receptors, antagonists, Presynaptic, cholinergic, modulators, Muscarinic, Acetylcholine, release, Nicotinic, nAChR, Tocris Bioscience, Other Acetylcholine Modulator products
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November 12 - 16, 2016
San Diego, CA, USA