Cat. No. 3070
Chemical Name: 10-[2-(1-Methyl-2-piperidinyl)ethyl
Biological ActivityDopamine receptor antagonist that displays antipsychotic activity. Exhibits anticancer activity in cervical, endometrial and breast cancer cells; triggers apoptosis by targeting the PI 3-K/Akt/mTOR/p70 S6K pathway. Induces G1 cell cycle arrest. Selective inducer of cancer stem cell (CSC) differentiation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Kang et al (2012) Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis. Mar 30 Epub ahead of print. PMID: 22460505.
Sachlos et al (2012) Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells. Cell. May 23. Epub ahead of print. PMID: 22632761.
Merck Index 13 9435.
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Citations are publications that use Tocris products. Selected citations for Thioridazine hydrochloride include:
Chigaev et al (2011) Discovery of very late antigen-4 (VLA-4, alpha4beta1 integrin) allosteric antagonists. J Biol Chem 286 5455. PMID: 21131351.
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Keywords: Thioridazine hydrochloride, supplier, Dopamine, receptor, antagonists, antipsychotic, D2-like, Non-Selective, Receptors, dopaminergic, anticancer, Tocris Bioscience, Non-selective Dopamine Antagonist products