Desipramine hydrochloride

Cat. No. 3067

Desipramine hydrochloride C18H22N2.HCl [58-28-6]

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Chemical Name: 10-11-Dihydro-N-methyl-5H-dibenz(Z)[b,f]azepine-5-propanamine hydrochloride

Biological Activity

Tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (Ki values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively).

Technical Data

M.Wt:
302.84
Formula:
C18H22N2.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
58-28-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Zhao et al (2008) Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine. Neuropsychopharmacol. 33 3190.

Torres et al (2003) Plasma membrane monoamine transporters: structure, regulation and function. Nat.Rev.Neurosci. 4 13. PMID: 12511858.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Desipramine hydrochloride include:

Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. Proc Natl Acad Sci U S A 40 766. PMID: 25249058.

LaRocca et al (2015) CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis. Neuropsychopharmacology 6 e1773. PMID: 26018734.

Bucher et al (2014) Medullary norepinephrine neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis. J Cereb Blood Flow Metab 34 1128. PMID: 24714037.

Choi et al (2013) Changes in c-Fos Expression in the Forced Swimming Test: Common and Distinct Modulation in Rat Brain by Desipramine and Citalopram. Korean J Physiol Pharmacol 17 321. PMID: 23946692.

Do you know of a great paper that uses Desipramine hydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Desipramine hydrochloride, supplier, Selective, inhibitors, inhibits, noradrenaline, transporters, Transporter, NET, Adrenergic, Monoamine, Neurotransmitter, Tocris Bioscience, Adrenergic Transporter Inhibitor products

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