Cat. No. 3067
Chemical Name: 10-11-Dihydro-N-methyl-5H-dibenz(Z)
Biological ActivityTricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (Ki values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Zhao et al (2008) Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine. Neuropsychopharmacol. 33 3190.
Torres et al (2003) Plasma membrane monoamine transporters: structure, regulation and function. Nat.Rev.Neurosci. 4 13. PMID: 12511858.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Desipramine hydrochloride include:
Bucher et al (2014) Medullary norepinephrine neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis. J Cereb Blood Flow Metab 34 1128. PMID: 24714037.
Choi et al (2013) Changes in c-Fos Expression in the Forced Swimming Test: Common and Distinct Modulation in Rat Brain by Desipramine and Citalopram. Korean J Physiol Pharmacol 17 321. PMID: 23946692.
Do you know of a great paper that uses Desipramine hydrochloride from Tocris? If so please let us know.
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Keywords: Desipramine hydrochloride, supplier, Selective, inhibitors, inhibits, noradrenaline, transporters, Transporter, NET, Adrenergic, Monoamine, Neurotransmitter, Tocris Bioscience, Adrenergic Transporter Inhibitor products
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