1-Naphthyl PP1

Cat. No. 3063

1-Naphthyl PP1 C19H19N5 [221243-82-9]

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Alternative Name: 1-NA-PP 1

Chemical Name: 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Biological Activity

Selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).

Technical Data

M.Wt:
317.39
Formula:
C19H19N5
Solubility:
Soluble to 20 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
221243-82-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Bishop et al (2000) A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407 395. PMID: 11014197.

Bishop et al (1999) Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. J.Am.Chem.Soc. 121 627.

If you know of a relevant reference for 1-Naphthyl PP1 please let us know.

Citations are publications that use Tocris products. Selected citations for 1-Naphthyl PP1 include:

Chen et al (2015) Phosphorylation of the Synaptonemal Complex Protein Zip1 Regulates the Crossover/Noncrossover Decision during Yeast Meiosis. PLoS Biol 13 e1002329. PMID: 26682552.

Meyer et al (2015) Ipl1/Aurora-B is necessary for kinetochore restructuring in meiosis I in Saccharomyces cerevisiae. Genes Dev 26 2986. PMID: 26157162.

Kim et al (2013) Dual mechanisms prevent premature chromosome segregation during meiosis. Cell Death Dis 27 2139. PMID: 24115770.

Lo and Hollingsworth (2011) Using the semi-synthetic epitope system to identify direct substrates of the meiosis-specific budding yeast kinase, Mek1. Methods Mol Biol 745 135. PMID: 21660693.

Do you know of a great paper that uses 1-Naphthyl PP1 from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: 1-Naphthyl PP1, supplier, Src, family, kinase, inhibits, inhibitors, c-Abl, v-Src, c-Fyn, 1-NaphthylPP1, 1NAPP1, Tocris Bioscience, Src Kinase Inhibitor products

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