NS 1643

Cat. No. 3062

NS 1643 C15H10F6N2O3 [448895-37-2]

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Chemical Name: N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea

Biological Activity

Human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM). Exhibits different molecular mechanisms of action at KV11.1 (hERG1) and KV11.2 (hERG2) channels. Displays antiarrhythmic activity in vitro.

Technical Data

Soluble to 100 mM in ethanol and to 25 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Elmedyb et al (2007) Activation of ERG2 potassium channel by the diphenylurea NS1643. Neuropharmacology 53 283. PMID: 17610913.

Casis et al (2006) Mechanism of action of a novel human ether-a-go-ao related gene channel activator. Mol.Pharmacol. 69 658. PMID: 16284303.

Hansen et al (2006) Activation of human ether-a-go-go related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643). Mol.Pharmacol. 69 266. PMID: 16219910.

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Keywords: NS 1643, supplier, hERG, channel, activators, Antiarrhythmic, Potassium, KV, Channels, Human, Ether-A-Go-Go, Gene, voltage-gated, voltage-dependent, K+, NS1643, Tocris Bioscience, Voltage-gated Potassium (KV) Channel Activator products

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