Cat. No. 3062
Chemical Name: N,N'-Bis[2-hydroxy-5-(trifluoromethy
Biological ActivityHuman ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM). Exhibits different molecular mechanisms of action at KV11.1 (hERG1) and KV11.2 (hERG2) channels. Displays antiarrhythmic activity in vitro.
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Elmedyb et al (2007) Activation of ERG2 potassium channel by the diphenylurea NS1643. Neuropharmacology 53 283. PMID: 17610913.
Casis et al (2006) Mechanism of action of a novel human ether-a-go-ao related gene channel activator. Mol.Pharmacol. 69 658. PMID: 16284303.
Hansen et al (2006) Activation of human ether-a-go-go related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643). Mol.Pharmacol. 69 266. PMID: 16219910.
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Keywords: NS 1643, supplier, hERG, channel, activators, Antiarrhythmic, Potassium, KV, Channels, Human, Ether-A-Go-Go, Gene, voltage-gated, voltage-dependent, K+, NS1643, Tocris Bioscience, Voltage-gated Potassium (KV) Channel Activator products