Cat. No. 3062
Chemical Name: N,N'-Bis[2-hydroxy-5-(trifluoromethy
Biological ActivityHuman ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM). Exhibits different molecular mechanisms of action at KV11.1 (hERG1) and KV11.2 (hERG2) channels. Displays antiarrhythmic activity in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Elmedyb et al (2007) Activation of ERG2 potassium channel by the diphenylurea NS1643. Neuropharmacology 53 283. PMID: 17610913.
Casis et al (2006) Mechanism of action of a novel human ether-a-go-ao related gene channel activator. Mol.Pharmacol. 69 658. PMID: 16284303.
Hansen et al (2006) Activation of human ether-a-go-go related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643). Mol.Pharmacol. 69 266. PMID: 16219910.
If you know of a relevant reference for NS 1643 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses NS 1643 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: NS 1643, supplier, hERG, channel, activators, Antiarrhythmic, Potassium, KV, Channels, Human, Ether-A-Go-Go, Gene, voltage-gated, voltage-dependent, K+, NS1643, Tocris Bioscience, Voltage-gated Potassium (KV) Channel Activator products
Find multiple products by catalog number
New Products in this Area
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.