Cat. No. 3061
Chemical Name: (15R)-6,17-Didemethoxy-15-methoxy-6
Biological ActivityAnsamycin antibiotic compound that inhibits Hsp90 activity (IC50 = 2 μM) by binding to the ATP-binding site. Exhibits antitumor and cytocidal activities (IC50 ~ 0.4 μM) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. Displays higher affinity and potency than geldanamycin (Cat. No. 1368).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Martin et al (2008) Molecular characterization of macbecin as an Hsp90 inhibitor. J.Med.Chem. 51 2853. PMID: 18357975.
Uehara et al (2003) Natural product origins of Hsp90 inhibitors. Curr.Cancer Drug Targets 3 325. PMID: 14529384.
Ono et al (1982) Antitumor and cytocidal activities of a newly isolated benzenoid ansamycin, macbecin I. Gann. 73 938. PMID: 6186564.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Macbecin I from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Macbecin I, supplier, Hsp90, inhibitors, inhibits, Heat, Shock, Protein, 90, MacbecinI, antibiotics, Tocris Bioscience, Hsp90 Inhibitor products
Find multiple products by catalog number
March 18 - 22, 2017
Little Rock, ARK, USA