Cat. No. 3061
Chemical Name: (15R)-6,17-Didemethoxy-15-methoxy-6
Biological ActivityAnsamycin antibiotic compound that inhibits Hsp90 activity (IC50 = 2 μM) by binding to the ATP-binding site. Exhibits antitumor and cytocidal activities (IC50 ~ 0.4 μM) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. Displays higher affinity and potency than geldanamycin (Cat. No. 1368).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Martin et al (2008) Molecular characterization of macbecin as an Hsp90 inhibitor. J.Med.Chem. 51 2853. PMID: 18357975.
Uehara et al (2003) Natural product origins of Hsp90 inhibitors. Curr.Cancer Drug Targets 3 325. PMID: 14529384.
Ono et al (1982) Antitumor and cytocidal activities of a newly isolated benzenoid ansamycin, macbecin I. Gann. 73 938. PMID: 6186564.
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Keywords: Macbecin I, supplier, Hsp90, inhibitors, inhibits, Heat, Shock, Protein, 90, MacbecinI, antibiotics, Tocris Bioscience, Hsp90 Inhibitor products