Cat. No. 0919
Chemical Name: 1-(2-Trifluoromethylphenyl)imidazol
Biological ActivityA potent inhibitor of neuronal and inducible NO synthases, with much lower affinity for the endothelial isoform (displays IC50 values of 28.2, 27.0 and 1057.5 μM respectively). Antinociceptive in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Tooker et al (2013) Nitric oxide mediates activity-dependent plasticity of retinal bipolar cell output via S-nitrosylation. J.Neurosci. 33 19176. PMID: 24305814.
Handy et al (1996) Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl)imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects. Br.J.Pharmacol. 119 423. PMID: 8886430.
Handy et al (1995) The antinociceptive effect of 1-(2-trifluoromethylphenyl)imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br.J.Pharmacol. 116 2349. PMID: 8581267.
If you know of a relevant reference for TRIM please let us know.
Citations are publications that use Tocris products. Selected citations for TRIM include:
Zanardo et al (1997) Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils. Proc Natl Acad Sci U S A 94 14111. PMID: 9391161.
Do you know of a great paper that uses TRIM from Tocris? If so please let us know.
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Keywords: TRIM, supplier, nNOS/iNOS, inhibitors, inhibits, Non-Selective, NOS, Nitric, Oxide, Signaling, Signalling, NO, Synthases, Tocris Bioscience, Non-selective NOS Inhibitor products