Pentoxifylline

Cat. No. 3056

Pentoxifylline C13H18N4O3 [6493-05-6]

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Alternative Name: PTX

Chemical Name: 3,7-Dimethyl-1-(5-oxohexyl)xanthine

Biological Activity

Phosphodiesterase inhibitor that blocks production of TNF-α and other cytokines. Displays antinociceptive activity.

Technical Data

M.Wt:
278.31
Formula:
C13H18N4O3
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
6493-05-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Vale et al (2004) Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain. Br.J.Pharmacol. 143 833. PMID: 15520047.

Monshouwer et al (1996) Differential effect of pentoxifylline on lipopolysaccharide-induced downregulation of cytochrome P450. Biochem.Pharmacol. 52 1195. PMID: 8937426.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Pentoxifylline include:

Liu et al (2015) A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis. Sci Signal 8 ra71. PMID: 26198357.

Malyshev et al (2015) Advantages and limitations of the use of optogenetic approach in studying fast-scale spike encoding. PLoS One 10 e0122286. PMID: 25850004.

Penzo and Peña (2009) Endocannabinoid-mediated long-term depression in the avian midbrain expressed presynaptically and postsynaptically. J Neurosci 29 4131. PMID: 19339608.

Jakubs et al (2006) Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability. Neuron 52 1047. PMID: 17178407.

Pierre et al (2004) PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate. EMBO J 23 3031. PMID: 15257286.

Do you know of a great paper that uses Pentoxifylline from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Product Action

Keywords: Pentoxifylline, supplier, PDE, inhibitors, inhibits, Phosphodiesterases, Tocris Bioscience, Phosphodiesterase Inhibitor products

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