Cat. No. 3056
Alternative Name: PTX
Chemical Name: 3,7-Dimethyl-1-(5-oxohexyl)xanthine
Biological ActivityPhosphodiesterase inhibitor that blocks production of TNF-α and other cytokines. Displays antinociceptive activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Vale et al (2004) Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain. Br.J.Pharmacol. 143 833. PMID: 15520047.
Monshouwer et al (1996) Differential effect of pentoxifylline on lipopolysaccharide-induced downregulation of cytochrome P450. Biochem.Pharmacol. 52 1195. PMID: 8937426.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Pentoxifylline include:
Liu et al (2015) A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis. Sci Signal 8 ra71. PMID: 26198357.
Malyshev et al (2015) Advantages and limitations of the use of optogenetic approach in studying fast-scale spike encoding. PLoS One 10 e0122286. PMID: 25850004.
Penzo and Peña (2009) Endocannabinoid-mediated long-term depression in the avian midbrain expressed presynaptically and postsynaptically. J Neurosci 29 4131. PMID: 19339608.
Jakubs et al (2006) Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability. Neuron 52 1047. PMID: 17178407.
Pierre et al (2004) PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate. EMBO J 23 3031. PMID: 15257286.
View Related Products by Product Action
Keywords: Pentoxifylline, supplier, PDE, inhibitors, inhibits, Phosphodiesterases, Tocris Bioscience, Phosphodiesterase Inhibitor products
Find multiple products by catalog number
New Products in this Area
HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidantpCPA methyl ester hydrochloride
Tryptophan hydroxylase inhibitor
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.