Cat. No. 3056

Pentoxifylline C13H18N4O3 [6493-05-6]

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Alternative Name: PTX

Chemical Name: 3,7-Dimethyl-1-(5-oxohexyl)xanthine

Biological Activity

Phosphodiesterase inhibitor that blocks production of TNF-α and other cytokines. Displays antinociceptive activity.

Technical Data

Soluble to 100 mM in water
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Vale et al (2004) Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain. Br.J.Pharmacol. 143 833. PMID: 15520047.

Monshouwer et al (1996) Differential effect of pentoxifylline on lipopolysaccharide-induced downregulation of cytochrome P450. Biochem.Pharmacol. 52 1195. PMID: 8937426.

If you know of a relevant reference for Pentoxifylline please let us know.

Citations are publications that use Tocris products. Selected citations for Pentoxifylline include:

Guidi et al (2015) Impaired attention and synaptic senescence of the prefrontal cortex involves redox regulation of NMDA receptors. PLoS One 35 3966. PMID: 25740525.

Liu et al (2015) A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis. Sci Signal 8 ra71. PMID: 26198357.

Malyshev et al (2015) Advantages and limitations of the use of optogenetic approach in studying fast-scale spike encoding. PLoS One 10 e0122286. PMID: 25850004.

Park (2015) Maresin 1 Inhibits TRPV1 in Temporomandibular Joint-Related Trigeminal Nociceptive Neurons and TMJ Inflammation-Induced Synaptic Plasticity in the Trigeminal Nucleus. J Neurosci 2015 275126. PMID: 26617436.

Simonson et al (2015) Pharmacology and anti-addiction effects of the novel κ opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A. Mol Biol Cell 172 515. PMID: 24641310.

Thueson et al (2015) In vitro exposure to the herbicide atrazine inhibits T cell activation, proliferation, and cytokine production and significantly increases the frequency of Foxp3+ regulatory T cells. Sci Rep 143 418. PMID: 25433234.

Wang et al (2015) β2 adrenergic receptor activation governs cardiac repolarization and arrhythmogenesis in a guinea pig model of heart failure. Mediators Inflamm 5 7681. PMID: 25567365.

Zhang et al (2015) GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Toxicol Sci 5 10468. PMID: 26020477.

Bailes et al (2012) Reproducible and sustained regulation of Gαs signalling using a metazoan opsin as an optogenetic tool. Dev Neurobiol 7 e30774. PMID: 22292038.

Zhang et al (2011) Developmental maturation of excitation and inhibition balance in principal neurons across four layers of somatosensory cortex. Br J Pharmacol 174 45931. PMID: 21115101.

Zhang and Sun (2011) Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons. Neuroscience 71 221. PMID: 20936660.

Penzo and Peña (2009) Endocannabinoid-mediated long-term depression in the avian midbrain expressed presynaptically and postsynaptically. J Neurosci 29 4131. PMID: 19339608.

Jakubs et al (2006) Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability. Neuron 52 1047. PMID: 17178407.

Pierre et al (2004) PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate. EMBO J 23 3031. PMID: 15257286.

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Keywords: Pentoxifylline, supplier, PDE, inhibitors, inhibits, Phosphodiesterases, Tocris Bioscience, Phosphodiesterase Inhibitor products

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