Cat. No. 3054
Biological ActivitySelective vasoactive intestinal peptide (VIP) receptor antagonist (IC50 = 125.8 nM). Displays no activity on glucagon, secretin or GRF receptors.
(Modifications: Phe-6 = p-Cl-D-Phe, Asn-34 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Xie et al (2007) Vasoactive intestinal peptide transactivates the androgen receptor through a protein kinase A-dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cells. Mol.Pharmacol. 72 73. PMID: 17430995.
Pozo et al (1997) Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages. Eur.J.Pharmacol. 321 379. PMID: 9085051.
Pandol et al (1986) Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe6,Leu17]VIP. Am.J.Physiol. 250 G553. PMID: 2421587.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for [D-p-Cl-Phe6,Leu17]-VIP include:
Jones et al (2015) Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior. Nat Neurosci 18 373. PMID: 25643294.
Nedvetsky et al (2014) Parasympathetic innervation regulates tubulogenesis in the developing salivary gland. Dev Cell 30 449. PMID: 25158854.
Evans et al (2013) Dynamic interactions mediated by nonredundant signaling mechanisms couple circadian clock neurons. Neuron 80 973. PMID: 24267653.
Do you know of a great paper that uses [D-p-Cl-Phe6,Leu17]-VIP from Tocris? If so please let us know.
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Keywords: [D-p-Cl-Phe6,Leu17]-VIP, supplier, Selective, VIP, receptor, antagonists, Vasoactive, Intestinal, Peptide, Receptors, VPAC, Tocris Bioscience, VIP Receptor Antagonist products
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