[D-p-Cl-Phe6,Leu17]-VIP

Cat. No. 3054

[D-p-Cl-Phe6,Leu17]-VIP His-Ser-Asp-Ala-Val-p-Cl-D-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Leu-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2

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Biological Activity

Selective vasoactive intestinal peptide (VIP) receptor antagonist (IC50 = 125.8 nM). Displays no activity on glucagon, secretin or GRF receptors.

Technical Data

M.Wt:
3342.24
Formula:
C148H239ClN44O42
Sequence:
HSDAVFTDNYTRLRKQLAVKKYLNSILN

(Modifications: Phe-6 = p-Cl-D-Phe, Asn-34 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
102805-45-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Xie et al (2007) Vasoactive intestinal peptide transactivates the androgen receptor through a protein kinase A-dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cells. Mol.Pharmacol. 72 73. PMID: 17430995.

Pozo et al (1997) Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages. Eur.J.Pharmacol. 321 379. PMID: 9085051.

Pandol et al (1986) Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe6,Leu17]VIP. Am.J.Physiol. 250 G553. PMID: 2421587.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for [D-p-Cl-Phe6,Leu17]-VIP include:

Maugeri et al (2016) PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression. Sci Rep 7 139. PMID: 27303300.

Jones et al (2015) Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior. Nat Neurosci 18 373. PMID: 25643294.

Nedvetsky et al (2014) Parasympathetic innervation regulates tubulogenesis in the developing salivary gland. Dev Cell 30 449. PMID: 25158854.

Evans et al (2013) Dynamic interactions mediated by nonredundant signaling mechanisms couple circadian clock neurons. Neuron 80 973. PMID: 24267653.

Do you know of a great paper that uses [D-p-Cl-Phe6,Leu17]-VIP from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: [D-p-Cl-Phe6,Leu17]-VIP, supplier, Selective, VIP, receptor, antagonists, Vasoactive, Intestinal, Peptide, Receptors, VPAC, Tocris Bioscience, VIP Receptor Antagonist products

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