Mesopram

Cat. No. 3053

Mesopram C14H19NO4 [189940-24-7]

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Chemical Name: (R)-5-(4-Methoxy-3-propoxyphenyl)-5-methyl-2-oxazolidinone

Biological Activity

Orally active phosphodiesterase (PDE) 4 inhibitor. Inhibits Th1 cell proliferation and decreases production of IFN-γ, TNF-α, IL-10 and iNOS in vitro. Triggers ovulation and exhibits efficacy against experimental autoimmune encephalomyelitis and murine colitis in vivo.

Technical Data

M.Wt:
265.31
Formula:
C14H19NO4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
189940-24-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

McKenna et al (2005) Pharmacological inhibition of phosphodiesterase 4 triggers ovulation in follicle-stimulating hormone-primed rats. Endocrinology 146 208. PMID: 15448112.

Loher et al (2003) The specific type-4 phosphodiesterase inhibitor mesopram alleviates experimental colitis in mice. J.Pharmacol.Exp.Ther. 305 549. PMID: 12606674.

Dinter et al (2000) The type IV phosphodiesterase specific inhibitor mesopram inhibits experimental autoimmune encephalomyelitis in rodents. J.Neuroimmunol. 108 136. PMID: 10900347.

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View Related Products by Product Action

Keywords: Mesopram, supplier, Orally, active, PDE4, inhibitors, inhibits, Phosphodiesterases, Tocris Bioscience, Phosphodiesterase Inhibitor products

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