Cat. No. 3053
Chemical Name: (R)-5-(4-Methoxy-3-propoxyphenyl)-5
Biological ActivityOrally active phosphodiesterase (PDE) 4 inhibitor. Inhibits Th1 cell proliferation and decreases production of IFN-γ, TNF-α, IL-10 and iNOS in vitro. Triggers ovulation and exhibits efficacy against experimental autoimmune encephalomyelitis and murine colitis in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
McKenna et al (2005) Pharmacological inhibition of phosphodiesterase 4 triggers ovulation in follicle-stimulating hormone-primed rats. Endocrinology 146 208. PMID: 15448112.
Loher et al (2003) The specific type-4 phosphodiesterase inhibitor mesopram alleviates experimental colitis in mice. J.Pharmacol.Exp.Ther. 305 549. PMID: 12606674.
Dinter et al (2000) The type IV phosphodiesterase specific inhibitor mesopram inhibits experimental autoimmune encephalomyelitis in rodents. J.Neuroimmunol. 108 136. PMID: 10900347.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Mesopram from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Mesopram, supplier, Orally, active, PDE4, inhibitors, inhibits, Phosphodiesterases, Tocris Bioscience, Phosphodiesterase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent PDE9 inhibitor; brain penetrantEggmanone
Potent and selective PDE4 inhibitor; suppresses hedgehog signalingAdaptaquin
HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant
December 13 - 15, 2016