Cat. No. 1308
Biological ActivitySelective and competitive nociceptin receptor antagonist, devoid of any agonist activity. Binds selectively to recombinant nociceptin receptors (pKi = 8.4), and competitively antagonizes the actions of nociceptin in vitro and in vivo.
(Modifications: Gly-1 = N-Bn-Gly, Lys-13 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Calo et al (2000) Characterization of [Nphe1]nociceptin(1-13)NH2, a new selective nociceptin receptor antagonist. Br.J.Pharmacol. 129 1183. PMID: 10725267.
Hashimoto et al (2000) Antagonistic effects of [Nphe1]nociceptin(1-13)NH2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor. Neurosci.Lett. 278 109. PMID: 10643813.
Pheng et al (2000) [Nphe1]nociceptin-(1-13)NH2 selectively antagonizes nociceptin effects in the rabbit isolated ileum. Eur.J.Pharmacol. 397 383. PMID: 10844138.
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Keywords: [NPhe1]Nociceptin(1-13)NH2, supplier, Selective, competitive, nociceptin, antagonists, Receptors, ORL1, OP4, NOP, Opioid, Tocris Bioscience, NOP Receptor Antagonist products
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