Cat. No. 3050
Chemical Name: 5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethy
Biological ActivitySelective α1A-adrenoceptor antagonist (pKi values are 9.97, 9.64 and 8.86 for α1A, α1B and α1D subtypes respectively). Decreases resting maximal urethral pressure with negligable effect on mean arterial blood pressure in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Ohtake et al (2005) Effects of tamsulosin on resting urethral pressure and arterial blood pressure in anaesthetized female dogs. J.Pharm.Pharmacol. 58 345.
Taguchi et al (1997) Effects of tamsulosin metabolites at alpha-1 adrenoceptor subtypes. J.Pharmacol.Exp.Ther. 280 1. PMID: 8996174.
Garcia-Sainz et al (1995) Alpha 1-adrenoceptor subtype selectivity of tamsulosin: studies using livers from different species. Eur.J.Pharmacol. 289 1. PMID: 7781702.
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Citations are publications that use Tocris products. Selected citations for Tamsulosin hydrochloride include:
Trevisani et al (2005) Hydrogen sulfide causes vanilloid receptor 1-mediated neurogenic inflammation in the airways. Br J Pharmacol 145 1123. PMID: 15937520.
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Keywords: Tamsulosin hydrochloride, supplier, Selective, α1A-adrenoceptor, alpha1A-adrenoceptor, a1a-adrenoceptor, α1a-adrenergic, alpha1a-adrenergic, a1a-adrenergic, antagonists, Receptors, Tocris Bioscience, Adrenergic α1 Receptor Antagonist products