Ciglitazone

Cat. No. 1307

Ciglitazone C18H23NO3S [74772-77-3]

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Chemical Name: 5-[[4-[(1-Methylcyclohexyl)methoxy]phenyl]methyl]-2,4-thiazolidinedione

Biological Activity

Selective agonist at PPARγ (peroxisome proliferator-activated receptor γ). Activates PPARγ with an EC50 value of 3 μM in vitro, and is at least 33-fold selective over PPARα and δ. Antihyperglycemic in vivo.

Technical Data

M.Wt:
333.44
Formula:
C18H23NO3S
Solubility:
Soluble to 100 mM in 1eq. NaOH
Purity:
>99 %
Storage:
Store at RT
CAS No:
74772-77-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Jh (1999) Thiazolidinediones - the new insulin enhancers. Clin.Exp.Hypertens. 21 157. PMID: 10052651.

Xin et al (1999) Peroxisome proliferator-activated receptor γ ligands are potent inhibitors of angiogenesis in vitro and in vivo. J.Biol.Chem. 274 9116. PMID: 10085162.

Willson et al (1996) The structure-activity relationship between peroxisome proliferator receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 39 665. PMID: 8576907.

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Keywords: Ciglitazone, supplier, Selective, PPARγ, PPARgamma, agonists, Peroxisome, Proliferating-activated, Receptors, Tocris Bioscience, PPARγ Agonist products

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