Cat. No. 1307
Chemical Name: 5-[[4-[(1-Methylcyclohexyl)methoxy]
Biological ActivitySelective agonist at PPARγ (peroxisome proliferator-activated receptor γ). Activates PPARγ with an EC50 value of 3 μM in vitro, and is at least 33-fold selective over PPARα and δ. Antihyperglycemic in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Jh (1999) Thiazolidinediones - the new insulin enhancers. Clin.Exp.Hypertens. 21 157. PMID: 10052651.
Xin et al (1999) Peroxisome proliferator-activated receptor γ ligands are potent inhibitors of angiogenesis in vitro and in vivo. J.Biol.Chem. 274 9116. PMID: 10085162.
Willson et al (1996) The structure-activity relationship between peroxisome proliferator receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 39 665. PMID: 8576907.
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Keywords: Ciglitazone, supplier, Selective, PPARγ, PPARgamma, agonists, Peroxisome, Proliferating-activated, Receptors, Tocris Bioscience, PPARγ Agonist products
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